Anti-Caspase-6 (P18) /CASP6 Antibody Picoband® fluoro488 Vervoeging

Caspase 6 is an enzyme that in humans is encoded by the caspase 6 gene. This gene encodes a protein that is a member of the cysteine-aspartic acid protease (caspase) family. Using radiation hybrid mapping, the Caspase 6 gene is localized to human chromosome 4q25-q26. Caspase 6 functions as a downstream enzyme in the caspase activation cascade. And Caspase 6 can cleave lamin A to its signature apoptotic fragment.

Caspase-6; CASP-6;3.4.22.59; Apoptotic protease Mch-2; Caspase-6 subunit p18; Caspase-6 subunit p11; Casp6; Mch2

CASP6

83584

O35397

Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of rat Caspase-6 (P18), different from the related mouse sequence by two amino acids.

Flow Cytometry

Alzheimer's Disease, Apoptosis, Apoptotic Markers, Cancer, Caspases, Cell Biology, Cell Death, Intracellular, Invasion/Microenvironment, Metabolism, Metabolism Processes, Neurodegenerative Disease, Neurology Process, Neuroscience, Pathways and Processes

Immunogen affinity purified.

Liquid

Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves poly (ADP-ribose) polymerase in vitro, as well as lamins. Overexpression promotes programmed cell death (By similarity) . .

1. Fernandes-Alnemri, T., Litwack, G., Alnemri, E. S.Mch2, a new member of the apoptotic Ced-3/Ice cysteine protease gene family.Cancer Res. 55: 2737-2742, 1995. 2. Nikolaev, A., McLaughlin, T., O'Leary, D. D. M., Tessier-Lavigne, M.APP binds DR6 to trigger axon pruning and neuron death via distinct caspases Nature 457: 981-989, 2009. 3. Orth, K., Chinnaiyan, A. M., Garg, M., Froelich, C. J., Dixit, V. M.The CED-3/ICE-like protease Mch2 is activated during apoptosis and cleaves the death substrate lamin A.J. Biol. Chem. 271: 16443-16446, 1996.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

31556 MW

No cross reactivity with other proteins.

6

Caspase-6

Cytoplasm .

Caspase-6

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.