Anti-Cathepsin D/CTSD Antibody Picoband® fluoro550 Vervoeging

Cathepsin D is a protein that in humans is encoded by the CTSD gene. This proteinase is a member of the peptidase C1 family, having a specificity similar to but narrower than that of pepsin A. It is mapped to 11p15.5. The cDNA encodes a 412-amino acid protein with 20 and 44 amino acids in a pre- and prosegment, respectively. Cathepsin D is one of the lysosomal proteinases. It is ubiquitously expressed and is involved in proteolytic degradation, cell invasion, and apoptosis. Mutations in this gene are involved in the pathogenesis of several diseases, including breast cancer and possibly Alzheimer disease and it has been considered as a breast cancer tumor marker.

Cathepsin D;3.4.23.5; Cathepsin D light chain; Cathepsin D heavy chain; CTSD; CPSD

CTSD

1509

P07339

Human

No cross-reactivity with other proteins

E.coli-derived human Cathepsin D recombinant protein (Position: G65-L412) . Human Cathepsin D shares 85% amino acid (aa) sequence identity with both mouse and rat Cathepsin D.

Expressed in the aorta extrcellular space (at protein level) . .

Flow Cytometry

Cancer, Cell Adhesion Proteins, Cell Biology, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Membrane Proteins, Neuroscience, Proteolysis/Ubiquitin, Proteolytic Enzymes, Signal Transduction

Immunogen affinity purified.

Liquid

Acid protease active in intracellular protein breakdown. Involved in the pathogenesis of several diseases such as breast cancer and possibly Alzheimer disease.

1. Faust PL, Kornfeld S, Chirgwin JM (Sep 1985) . Cloning and sequence analysis of cDNA for human cathepsin D. Proc Natl Acad Sci U S A 82 (15) : 4910–4. 2. Wolf M, Clark-Lewis I, Buri C, Langen H, Lis M, Mazzucchelli L (April 2003) . Cathepsin D specifically cleaves the chemokines macrophage inflammatory protein-1 alpha, macrophage inflammatory protein-1 beta, and SLC that are expressed in human breast cancer. Am. J. Pathol. 162 (4) : 1183–90.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

44552 MW

No cross reactivity with other proteins.

6

Cathepsin D

Lysosome. Melanosome. Secreted, extracellular space. Identified by mass spectrometry in melanosome fractions from stage I to stage IV. In aortic samples, detected as an extracellular protein loosely bound to the matrix (PubMed:20551380) . .

Belongs to the peptidase A1 family.

Cathepsin D

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.