Anti-Cathepsine B/CTSB Antibody Picoband® 31.0647 Vervoeging

Cathepsin B

Cathepsin B;3.4.22.1; APP secretase; APPS; Cathepsin B1; Cathepsin B light chain; Cathepsin B heavy chain; CTSB; CPSB

CTSB

1508

P07858

Human

No cross-reactivity with other proteins

E.coli-derived human Cathepsin B recombinant protein (Position: L80-D333) . Human Cathepsin B shares 83% and 84% amino acid (aa) sequences identity with mouse and rat Cathepsin B, respectively.

Expressed in all cell types so far analyzed.

Flow Cytometry

Angiogenesis, Cancer, Cell Adhesion, Cell Adhesion Proteins, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Invasion/Microenvironment, Membrane Proteins, Neuroscience, Signal Transduction

Immunogen affinity purified.

Liquid

Thiol protease which is believed to participate in intracellular degradation and turnover of proteins. Has also been implicated in tumor invasion and metastasis.

1. Chan SJ, San Segundo B, McCormick MB, Steiner DF (October 1986) . Nucleotide and predicted amino acid sequences of cloned human and mouse preprocathepsin B cDNAs. Proc. Natl. Acad. Sci. U.S.A. 83 (20) : 7721–5. 2. Cao L, Taggart RT, Berquin IM, Moin K, Fong D, Sloane BF (February 1994) . Human gastric adenocarcinoma cathepsin B: isolation and sequencing of full-length cDNAs and polymorphisms of the gene. Gene 139 (2) : 163–9. 3. Wang, X.; Chan, S. J.; Eddy, R. L.; Byers, M. G.; Fukushima, Y.; Henry, W. M.; Haley, L. L.; Steiner, D. F.; Shows, T. B. : Chromosome assignment of cathepsin B (CTSB) to 8p22 and cathepsin H (CTSH) to 15q24-q25. (Abstract) Cytogenet. Cell Genet. 46: 710-711, 1987. 4. Mueller-Steiner S, Zhou Y, Arai H, Roberson ED, Sun B, Chen J, Wang X, Yu G, Esposito L, Mucke L, Gan L (September 2006) . Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease. Neuron 51 (6) : 703–14.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

37822 MW

No cross reactivity with other proteins.

6

Cathepsin B

Lysosome. Melanosome. Secreted, extracellular space . Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

Belongs to the peptidase C1 family.

Cathepsin B

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.