Anti-Cathepsine L Ctsl Antilichaam (Monoclonal, 33/2)

Cathepsin L is a lysosomal cysteine proteinase with a major role in intracellular protein catabolism. It also shows the most potent collagenolytic and elastinolytic activity in vitro of any of the cathepsins. Cathepsin L has been implicated in pathologic processes including myofibril necrosis in myopathies and in myocardial ischemia, and in the renal tubular response to proteinuria. Human liver cathepsin L consists of a heavy chain of about 25 kD and a light chain of about 5 kD. The gene is mapped to 9q21-q22. Cathepsin L is required for endothelial progenitor cell-induced neovascularization.

Boster Bio Anti-Cathepsin L Ctsl Antibody (Monoclonal, 33/2) catalog # MA1014. Tested in IHC, WB applications. This antibody reacts with Human, Mouse, Rat.

Cathepsin L1;3.4.22.15; Cathepsin L; Cyclic protein 2; CP-2; Major excreted protein; MEP; Procathepsin L; Cathepsin L1 heavy chain; Cathepsin L1 light chain; Ctsl; Ctsl1

CTSL1

Human (1514), Mouse (13039), Rat (25697)

P07154

Human, Mouse, Rat

No cross-reactivity with other proteins

Procathepsin L isolated from the human lung cancer cell line EPLC 32M1.

Clone: 33/2

Both mature cathepsin L1 and procathepsin L are found in the upper epidermis. The lower epidermis predominantly contains procathepsin L. In seminiferous tubules expression is greater at stages VI-VII than at stages IX-XII. .

IHC, WB

Cell Adhesion Proteins, Cytoskeleton/ECM, ECM Enzymes, Extracellular Matrix, Membrane Proteins, Neuroscience, Signal Transduction

Ascites

Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Lyophilized

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Important for the overall degradation of proteins in lysosomes. Procathepsin L is required for maximal stimulation of steroidogenesis by TIMP1. .

1. Fan, Y.-S.; Byers, M. G.; Eddy, R. L.; Joseph, L.; Sukhatme, V.; Chan, S.-J.; Shows, T. B. : Cathepsin L (CTSL) is located in the chromosome 9q21-q22 region: a related sequence is located on chromosome 10. (Abstract) Cytogenet. Cell Genet. 51: 996 only, 1989. 2. Urbich, C.; Heeschen, C.; Aicher, A.; Sasaki, K.; Bruhl, T.; Farhadi, M. R.; Vajkoczy, P.; Hofmann, W. K.; Peters, C.; Pennacchio, L. A.; Abolmaali, N. D.; Chavakis, E.; Reinheckel, T.; Zeiher, A. M.; Dimmeler, S. : Cathepsin L is required for endothelial progenitor cell-induced neovascularization. Nature Med. 11: 206-213, 2005.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=MA1014

37660 MW

25 kDa

No cross reactivity with other proteins.

Cathepsin L1

Lysosome .

Belongs to the peptidase C1 family.

Cathepsin L1

Mouse IgG1

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.