Anti-Cav alfa2 delta2 (N492/39) Recombinant kip Chimeric mAb FL490 Conjugate

Cav α2δ2 is an auxiliary subunit of voltage-gated calcium channels that modulates channel trafficking, gating, and pharmacological properties. Encoded by the CACNA2D2 gene, this glycoprotein is synthesized as a single precursor that is post-translationally cleaved into the extracellular α2 and membrane-anchored δ2 subunits, linked by disulfide bonds. Cav α2δ2 enhances calcium current density by promoting the proper trafficking of pore-forming Cavα1 subunits to the plasma membrane and stabilizing them at synaptic sites. It plays a key role in neurotransmitter release, synaptic plasticity, and neuronal excitability. Altered expression or mutation of CACNA2D2 has been associated with neurological disorders, including epilepsy, cerebellar ataxia, and certain cancers, underscoring its importance in calcium channel regulation and disease pathophysiology.

Our chicken Anti-Cav alpha2 delta2 recombinant monoclonal antibody is a chimeric antibody derived from NeuroMab clone N492/39. It detects human, mouse, and rat Cav alpha2 delta2, and is purified by affinity chromatography. It is great for use in ICC, IHC.

Our chicken Anti-Cav alpha2 delta2 recombinant monoclonal antibody is a chimeric antibody derived from NeuroMab clone N492/39. It detects human, mouse, and rat Cav alpha2 delta2, and is purified by affinity chromatography. It is great for use in ICC, IHC.

Voltage-dependent R-type calcium channel subunit alpha-2/delta-2, Cacna2d2

Cacna2d2

Human, Mouse, and Rat

Recombinant protein amino acids 61-197 (extracellular domain) of mouse Cav alpha2 delta2 (also known as voltage-dependent R-type calcium channel subunit alpha-2/delta-2, Cacna2d2, accession number Q6PHS9) produced recombinantly in E.Coli.

Cav alpha2 delta2

N492/39

FL490 Ex: 491 nm, Em: 515 nm

ICC, IHC

Cell Markers/Ion Channels and Modulators/Ca2+ Channels/

Primary Antibodies

0.5 mg/mL

Purified by affinity chromatography

Liquid

7.4

130 kDa

These antibodies are to be used as research laboratory reagents and are not for use as diagnostic or therapeutic reagents in humans.

Shipped on ice packs

Aliquot and store at ≤ -20°C for long term storage. For short term storage, store at 2-8°C. For maximum recovery of product, centrifuge the vial prior to removing the cap.

This recombinant antibody is a chimeric antibody created by replacing the mouse heavy and light constant regions of clone N492/39 with chicken IgY heavy and light constant regions. As such this antibody retains the same binding performance as the original clone N492/39 but can be detected using standard anti-chicken secondary antibodies allowing flexibility for multiplexing applications. This antibody is expressed recombinantly in mammalian cells and then affinity purified from the cell culture media and conjugated.

No cross-reactivity reported

Each new lot of antibody is quality control tested by Western blot on rat brain membrane fraction and confirmed to stain the expected molecular weight band.

Q6PHS9

IgY

Mouse

Quality Control: WB Brain