Anti-CCDC115 Antibody Picoband® 31.0550 Vervoeging

Coiled-coil domain containing 115 is a protein that in humans is encoded by the CCDC115 gene. The protein encoded by this gene has been observed to localize to the endoplasmic reticulum (ER) -Golgi intermediate compartment (ERGIC) and coat protein complex I (COPI) vesicles in some human cells. The encoded protein shares some homology with the yeast V-ATPase assembly factor Vma22p, and the orthologous protein in mouse promotes cell proliferation and suppresses cell death. Defects in this gene are a cause of congenital disorder of glycosylation, type IIo in humans.

RNA-binding protein 47; RNA-binding motif protein 47; RBM47

CCDC115

84317

Q96NT0

Human

No cross-reactivity with other proteins

E.coli-derived human CCDC115 recombinant protein (Position: M1-A180) .

Abundantly expressed in tonsil, lymph node, and trachea; strong expression in prostate; lower expression in thyroid, stomach, and colon. .

Flow Cytometry

Chromatin Binding Proteins, DNA/RNA Binding, Epigenetics and Nuclear Signaling

Immunogen affinity purified.

Liquid

Can bind to the surface of B-lymphoma cells, but not T- lymphoma cells, consistent with a function as a secreted mediator acting upon B-cells.

1. D., Krawitz, P., Wada, Y., Ashikov, A., Perez-Cerda, C., and 31 others. CCDC115 deficiency causes a disorder of Golgi homeostasis with abnormal protein glycosylation. Am. J. Hum. Genet. 98: 310-321, 2016. 2. Pellicano, F., Inglis-Broadgate, S. L., Pante, G., Ansorge, W., Iwata, T. Expression of coiled-coil protein 1, a novel gene downstream of FGF2, in the developing brain. Gene Expr. Patterns 6: 285-293, 2006. 3. Pellicano, F., Thomson, R. E., Inman, G. J., Iwata, T. Regulation of cell proliferation and apoptosis in neuroblastoma cells by ccp1, a FGF2 downstream gene. BMC Cancer 10: 657, 2010. Note: Electronic Article.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

64099 MW

6

RNA-binding protein 47

Nucleus .

Follicular dendritic cell secreted peptide

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.