Anti-CCDC86 Antilichaam

CCDC86 (Coiled-coil domain-containing protein 86), also known as Cyclon (cytokine-induced protein with coiled-coil domain) ) is known for its expression in leukocytes in mice, where it regulates the immune response. Cyclon/CCDC86 regulates the apoptosis of T-cells upon activation, a process known as an activationinduced cellular death (AICD), by regulating the expression of the death receptor Fas on T-cells (PMID: 23439384) . CCDC86 depletion led to a novel phenotype in which Ki-67 and nucleolin could still accumulate at the chromosome periphery but also formed abnormal cytoplasmic NDF-like foci (PMID: 36695333) . The detected molecular weights (MWs) of Cyclon on SDS-PAGE (human Cyclon: 65 kDa; mouse Cyclon: 75 kDa) were higher than calculated MWs (human Cyclon: 40.2 kDa; mouse Cyclon: 46.5 kDa), suggesting possible modifications of Cyclon (PMID: 17300783) .

Boster Bio Anti-CCDC86 Antibody catalog # A10995-1. Tested in WB, ICC/IF, ELISA applications. This antibody reacts with Human, Mouse, Rat.

CCDC86

Q9H6F5

Human, Mouse, Rat

E.coli-derived human CCDC86 recombinant protein (Position: T3-A357) .

WB, ICC/IF, ELISA

Immunogen affinity purified.

500 μg/mL

Liquid

12 months from date of receipt, -20°C as supplied. 6 months 2 to 8°C after reconstitution. Avoid repeated freezing and thawing.

https://www.bosterbio.com/datasheet?sku=A10995-1

500 μg/mL antibody with PBS,0.02% NaN3, 1 mg BSA and 50% glycerol.