Anti-Ccl7 Antibody Picoband® 31.0550 Vervoeging

Chemokine (C-C motif) ligand 7 (CCL7) is a small cytokine known as a chemokine that was previously called monocyte-specific chemokine 3 (MCP3) . It belongs to the C-C chemokine family. By fluorescence in situ hybridization, MCP3 gene is mapped to chromosome 17q11.2-q12. MCP3 was identified as a physiologic substrate of gelatinase A. Cleaved MCP3 binds to CC-chemokine receptors-1, -2, and -3, but no longer induces calcium fluxes or promotes chemotaxis, and instead acts as a general chemokine antagonist that dampens inflammation, it has been found that matrix metalloproteinases are both effectors and regulators of the inflammatory response.

Fatty acid-binding protein, intestinal; Fatty acid-binding protein 2; Intestinal-type fatty acid-binding protein; I-FABP; Fabp2; Fabpi

Ccl7

287561

Q9QXY8

Rat

No cross-reactivity with other proteins

E.coli-derived rat Ccl7 recombinant protein (Position: Q24-P97) .

Expressed in the small intestine. Highest expression levels in the proximal ileum. .

Flow Cytometry

Calcium Binding Proteins, Calcium Signaling, Neuroscience, Neurotransmission

Immunogen affinity purified.

Liquid

FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long- chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor. .

1. Ong, V. H., Evans, L. A., Shiwen, X., Fisher, I. B., Rajkumar, V., Abraham, D. J., Black, C. M., Denton, C. P.Monocyte chemoattractant protein 3 as a mediator of fibrosis: overexpression in systemic sclerosis and the type 1 tight-skin mouse.Arthritis Rheum. 48: 1979-1991, 2003. 2. McQuibban, G. A., Gong, J.-H., Tam, E. M., McCulloch, C. A. G., Clark-Lewis, I., Overall, C. M.Inflammation dampened by gelatinase A cleavage of monocyte chemoattractant protein-3.Science 289: 1202-1206, 2000.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

15126 MW

6

Fatty acid-binding protein, intestinal

Cytoplasm.

Fatty acid-binding protein, intestinal

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.