Anti-CCR6/CCR6 Antibody Picoband® fluoro488 Vervoeging

CCR6, also termed CKRL3, encodes a 369-amino acid polypeptide with greatest similarity to the family of alpha-chemokine-binding receptors. Unlike most chemokine receptor genes, it is encoded by more than 1 exon. Weakly expressed as a 4-kb transcript in spleen, lymph nodes, peripheral blood lymphocytes and appendix, CCR6 gene is located at 6q27. As the receptor for MIP-3-alpha, its activation leads to phospholipase C-dependent intracellular Ca (2+) mobilization. Additionally, CCR6 are markedly upregulated in psoriasis.

C-C chemokine receptor type 6; C-C CKR-6; CC-CKR-6; CCR-6; Chemokine receptor-like 3; CKR-L3; DRY6; G-protein coupled receptor 29; GPR-CY4; GPRCY4; LARC receptor; CD196; CCR6; CKRL3, CMKBR6, GPR29, STRL22

CCR6

1235

P51684

Human, Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human CCR6, different from the related rat and mouse sequences by two amino acids.

Spleen, lymph nodes, appendix, and fetal liver. Expressed in lymphocytes, T-cells and B-cells but not in natural killer cells, monocytes or granulocytes.

Flow Cytometry

Chemokines, G Protein Signaling, Immunology, Innate Immunity, Signal Transduction, Signaling Pathway

Immunogen affinity purified.

Liquid

Receptor for a C-C type chemokine. Binds to MIP-3- alpha/LARC and subsequently transduces a signal by increasing the intracellular calcium ions level. .

1. Zaballos, A.; Varona, R.; Gutierrez, J.; Lind, P.; Marquez, G. : Molecular cloning and RNA expression of two new human chemokine receptor-like genes. Biochem. Biophys. Res. Commun. 227: 846-853, 1996. 2. Liao, F.; Lee, H.-H.; Farber, J. M. : Cloning of STRL22, a new human gene encoding a G-Protein-coupled receptor related to chemokine receptors and located on chromosome 6q27. Genomics 40: 175-180, 1997. 3. Homey, B.; Dieu-Nosjean, M.-C.; Wiesenborn, A.; Massacrier, C.; Pin, J.-J.; Oldham, E.; Catron, D.; Buchanan, M. E.; Muller, A.; de Waal Malefyt, R.; Deng, G.; Orozco, R.; Ruzicka, T.; Lehmann, P.; Lebecque, S.; Caux, C.; Zlotnik, A. : Up-regulation of macrophage inflammatory protein-3-alpha/CCL20 and CC chemokine receptor 6 in psoriasis. J. Immun. 164: 6621-6632, 2000.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

42494 MW

No cross reactivity with other proteins.

6

C-C chemokine receptor type 6

Cell membrane; Multi-pass membrane protein.

Belongs to the G-protein coupled receptor 1 family.

C-C chemokine receptor type 6 (C-C CKR-6/CC-CKR-6/CCR-6)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.