Anti-CCXCR1/XCR1 Antibody Picoband® fluoro488 Vervoeging

The protein encoded by this gene is a chemokine receptor belonging to the G protein-coupled receptor superfamily. The family members are characterized by the presence of 7 transmembrane domains and numerous conserved amino acids. This receptor is most closely related to RBS11 and the MIP1-alpha/RANTES receptor. It transduces a signal by increasing the intracellular calcium ions level. The viral macrophage inflammatory protein-II is an antagonist of this receptor and blocks signaling. Several alternatively spliced transcript variants encoding the same protein have been found for this gene.

NADH-ubiquinone oxidoreductase chain 4; NADH dehydrogenase subunit 4; Mtnd4; mt-Nd4; Nd4

XCR1

2829

P46094

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human CCXCR1/XCR1 recombinant protein (Position: F246-N274) .

Expressed in lung, on the vascular capillary network within alveolar walls, and also at lower level in kidney.

Flow Cytometry

Cell Type Markers, Tags & Cell Markers

Immunogen affinity purified.

Liquid

Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.

1. Gao, J.-L., Kuhns, D. B., Tiffany, H. L., McDermott, D., Li, X., Francke, U., Murphy, P. M. Structure and functional expression of the human macrophage inflammatory protein 1 alpha/RANTES receptor. J. Exp. Med. 177: 1421-1427, 1993. 2. Heiber, M., Docherty, J. M., Shah, G., Nguyen, T., Cheng, R., Heng, H. H. Q., Marchese, A., Tsui, L.-C., Shi, X., George, S. R., O'Dowd, B. F. Isolation of three novel human genes encoding G protein-coupled receptors. DNA Cell Biol. 14: 25-35, 1995. 3. Maho, A., Bensimon, A., Vassart, G., Parmentier, M. Mapping of the CCXCR1, CX3CR1, CCBP2 and CCR9 genes to the CCR cluster within the 3p21.3 region of the human genome. Cytogenet. Cell Genet. 87: 265-268, 1999.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

NADH dehydrogenase 4, mitochondrial

Mitochondrion membrane. Multi-pass membrane protein.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.