Anti-CD103/Itgae Antilichaam fluoro594 Vervoeging

ITGAE (INTEGRIN, ALPHA-E), also known as CD103, is an integrin protein that in human is encoded by the ITGAE gene. The ITGAE gene is mapped to chromosome 17p13 by inclusion within a BAC contig. ITGAE is expressed widely on intraepithelial lymphocyte (IEL) T cells (both alphabeta T cells and gammadelta T cells) and on some peripheral regulatory T cells (Tregs) which is important for decreasing the immune response and appears to play a crucial role in the prevention of autoimmune diseases. ITGAE shares overall homology with other alpha integrins but has a unique 55-amino acid extra region located just N-terminal to the I domain that contains 18 consecutive charged residues and a proteolytic cleavage site.

Ribosome-binding protein 1; 180 kDa ribosome receptor homolog; RRp; ES/130-related protein; Ribosome receptor protein; RRBP1; KIAA1398

Itgae

16407

Q60677

Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived mouse CD103/Itgae recombinant protein (Position: F20-E1061) .

Expressed in kidney.

Flow Cytometry

Cancer, DNA/RNA, Epigenetics and Nuclear Signaling, Ribosome, Translation, Tumor Biomarkers

Immunogen affinity purified.

Liquid

Acts as a ribosome receptor and mediates interaction between the ribosome and the endoplasmic reticulum membrane.

1. Cerf-Bensussan, N., Jarry, A., Brousse, N., Lisowska-Grospierre, B., Guy-Grand, D., Griscelli, C. A monoclonal antibody (HML-1) defining a novel membrane molecular present on human intestinal lymphocytes. Europ. J. Immun. 17: 1279-1285, 1987. 2. Parker, C. M., Cepek, K. L, Russell, G. J., Shaw, S. K., Posnett, D. N., Schwarting, R., Brenner, M. B. A family of beta-7 integrins on human mucosal lymphocytes. Proc. Nat. Acad. Sci. 89: 1924-1928, 1992. 3. Kilshaw PJ, Higgins JM (2002) . Alpha E: no more rejection?.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Ribosome binding protein 1

Endoplasmic reticulum membrane, Single-pass type III membrane protein.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.