Anti-CD11c/Itgax Antibody Picoband® 0,00647 Vervoeging

CD11c, also known as Integrin, alpha X (complement component 3 receptor 4 subunit) (ITGAX), is a genethat encodes for CD11c. This gene encodes the integrin alpha X chain protein. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This protein combines with the beta 2 chain (ITGB2) to form a leukocyte-specific integrin referred to as inactivated-C3b (iC3b) receptor 4 (CR4) . The alpha X beta 2 complex seems to overlap the properties of the alpha M beta 2 integrin in the adherence of neutrophils and monocytes to stimulated endothelium cells, and in the phagocytosis of complement coated particles. Two transcript variants encoding different isoforms have been found for this gene.

Integrin alpha-X; CD11 antigen-like family member C; Leu M5; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; CD11c; ITGAX; CD11C

Itgax

16411

Q9QXH4

Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived mouse CD11c/Itgax recombinant protein (Position: P140-T342) .

Predominantly expressed in monocytes and granulocytes.

Flow Cytometry

Cell Adhesion, Cell Type Markers, Cytoskeleton/ECM, Hematopoietic Progenitors, Immunology, Integrins, Lymphoid, Myeloid, Signal Transduction, Stem Cells, T Lymphocytic Lineage

Immunogen affinity purified.

Liquid

Integrin alpha-X/beta-2 is a receptor for fibrinogen. It recognizes the sequence G-P-R in fibrinogen. It mediates cell-cell interaction during inflammatory responses. It is especially important in monocyte adhesion and chemotaxis.

1. Entrez Gene: ITGAX integrin, alpha X (complement component 3 receptor 4 subunit) . 2. Córbi AL, Lopéz-Rodríguez C (1997) . CD11c integrin gene promoter activity during myeloid differentiation.. Leuk. Lymphoma. 25 (5-6) : 415–25.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

132494 MW

6

Integrin subunit alpha X

Membrane; Single-pass type I membrane protein.

Leptin receptor

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.