Anti-CD127/IL7R Antilichaam Picoband®

The interleukin-7 receptor, also known as IL7R alpha, is a protein found on the surface of cells. It is mapped to 5p13. Interleukin-7 receptor has been shown to play a critical role in the development of immune cells called lymphocytes - specifically in a process known as V (D) J recombination. This protein is also found to control the accessibility of a region of the genome that contains the T-cell receptor gamma gene, by STAT5 and histone acetylation. Knockout studies in mice suggest that blocking apoptosis is an essential function of this protein during differentiation and activation of T lymphocytes. Functional defects in this protein may be associated with the pathogenesis of severe combined immunodeficiency (SCID) .

Boster Bio Anti-CD127/IL7R Antibody Picoband® catalog # A02222-3. Tested in ELISA, IHC, WB, Flow Cytometry applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

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IL7R

3575

P16871

Human

No cross reactivity with other proteins.

E.coli-derived human CD127/IL7R recombinant protein (Position: A33-Q433) . Human IL7R shares 63.1% amino acid (aa) sequence identity with mouse IL7R.

Expressed in all tissues.

WB, IHC, Flow Cytometry, ELISA

Signal Transduction, Signaling Pathway, Small G Proteins

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Downstream effector of TOR signaling pathway involved in osmotic stress response. Could be involved in the control of plant growth and development. Phosphorylates the ribosomal proteins P14, P16 and S6. Functions as a repressor of cell proliferation and required for maintenance of chromosome stability and ploidy levels through the RBR1-E2F pathway.

1. Entrez Gene: IL7R interleukin 7 receptor. 2. Kroemer RT, Richards WG (December 1996) . Homology modeling study of the human interleukin-7 receptor complex.Protein Eng. 9 (12) : 1135–42. 3. O'Doherty C, Alloza I, Rooney M, Vandenbroeck K (November 2009) . IL7RA polymorphisms and chronic inflammatory arthropathies. Tissue Antigens 74 (5) : 429–31.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A02222-3

52588 MW

170 kDa

6

Serine/threonine-protein kinase AtPK1/AtPK6

Cytoplasm. Nucleus.

Serine/threonine-protein kinase AtPK1/AtPK6

IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.