Anti-CD1B Antibody Picoband® 31.0550 Vervoeging

CD1B is a member of the CD1 family of transmembrane glycoproteins, which are structurally related to the major histocompatibility complex (MHC) proteins and form heterodimers with beta-2-microglobulin. The CD1 proteins mediate the presentation of primarily lipid and glycolipid antigens of self or microbial origin to T cells. The human genome contains five CD1 family genes organized in a cluster on chromosome 1. The CD1 family members are thought to differ in their cellular localization and specificity for particular lipid ligands. The protein encoded by this gene localizes to late endosomes and lysosomes via a tyrosine-based motif in the cytoplasmic tail, and requires vesicular acidification to bind lipid antigens.

T-cell surface glycoprotein CD1b; CD1b; CD1B

CD1B

910

P29016

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human CD1B recombinant protein (Position: D78-Y110) .

Expressed on cortical thymocytes, on certain T-cell leukemias, and in various other tissues.

Flow Cytometry

Adaptive Immunity, B Cells, Cell Type Markers, Immunology, Non-CD

Immunogen affinity purified.

Liquid

Antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells.

1. Beckman, E. M., Porcelli, S. A., Morita, C. T., Behar, S. M., Furlong, S. T., Brenner, M. B. Recognition of a lipid antigen by CD1-restricted alpha-beta (+) T cells. Nature 372: 691-694, 1994. 2. Park, S.-H., Bendelac, A. CD1-restricted T-cell responses and microbial infection. Nature 406: 788-792, 2000. 3. Sieling, P. A., Chatterjee, D., Porcelli, S. A., Prigozy, T. I., Mazzaccaro, R. J., Soriano, T., Bloom, B. R., Brenner, M. B., Kronenberg, M., Brennan, P. J., Modlin, R. L. CD1-restricted T cell recognition of microbial lipoglycan antigens. Science 269: 227-230, 1995.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

63692 MW

6

CD1b molecule

Cell membrane.

Sentrin-specific protease 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.