Anti-CD20/MS4A1 Antibody Picoband®

CD20, also known as MS4A1, is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R+, CD117+) and progressively increasing in concentration until maturity. It is mapped to 11q12.2. This gene encodes a member of the membrane-spanning 4A gene family. The function of CD20 is to enable optimal B-cell immune response, specifically against T-independent antigens. It is suspected that CD20 acts as a calcium channel in the cell membrane. What’s more, this protein may be involved in the regulation of B-cell activation and proliferation.

Boster Bio Anti-CD20/MS4A1 Antibody Picoband® catalog # PB9050. Tested in Flow Cytometry, IF, IHC, IHC-F, ICC, WB applications. This antibody reacts with Human. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

B-lymphocyte antigen CD20; B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; CD20; MS4A1; CD20

MS4A1

931

P11836

Human

No cross-reactivity with other proteins

E.coli-derived human CD20 recombinant protein (Position: M1-D261) . Human CD20 shares 75% amino acid (aa) sequence identity with mouse CD20.

Expressed on B-cells.

Flow Cytometry, IF, IHC, IHC-F, ICC, WB

Adapters, Signal Transduction, Transmembrane

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Add 0.2ml of distilled water will yield a concentration of 500ug/ml.

This protein may be involved in the regulation of B-cell activation and proliferation.

1. Cragg MS, Walshe CA, Ivanov AO, Glennie MJ (2005) . The biology of CD20 and its potential as a target for mAb therapy. Curr. Dir. Autoimmun. Current ions in Autoimmunity 8: 140–74. 2. Hardy, Richard (2008) . Chapter 7: B Lymphocyte Development and Biology. In Paul, William.Fundamental Immunology (Book) (6th ed.) . Philadelphia: Lippincott Williams & Wilkins. pp. 237–269. 3. Kuijpers TW, Bende RJ, Baars PA, Grummels A, Derks IA, Dolman KM, Beaumont T, Tedder TF, van Noesel CJ, Eldering E, van Lier RA (January 2010) . CD20 deficiency in humans results in impaired T cell-independent antibody responses. J. Clin. Invest. 120 (1) : 214–22.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=PB9050

33077 MW

35 kDa

No cross reactivity with other proteins.

6

B-lymphocyte antigen CD20

Cell membrane ; Multi-pass membrane protein . Cell membrane ; Lipid-anchor .

Belongs to the MS4A family.

B-lymphocyte antigen CD20

Rabbit IgG

Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg NaN3.