Anti-CD20/MS4A1 Antibody Picoband® fluoro647 Vervoeging

CD20, also known as MS4A1, is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R+, CD117+) and progressively increasing in concentration until maturity. It is mapped to 11q12.2. This gene encodes a member of the membrane-spanning 4A gene family. The function of CD20 is to enable optimal B-cell immune response, specifically against T-independent antigens. It is suspected that CD20 acts as a calcium channel in the cell membrane. What’s more, this protein may be involved in the regulation of B-cell activation and proliferation.

B-lymphocyte antigen CD20; B-lymphocyte surface antigen B1; Bp35; Leukocyte surface antigen Leu-16; Membrane-spanning 4-domains subfamily A member 1; CD20; MS4A1; CD20

MS4A1

931

P11836

Human

No cross-reactivity with other proteins

E.coli-derived human CD20 recombinant protein (Position: M1-D261) . Human CD20 shares 75% amino acid (aa) sequence identity with mouse CD20.

Expressed on B-cells.

Flow Cytometry

Adapters, Signal Transduction, Transmembrane

Immunogen affinity purified.

Liquid

This protein may be involved in the regulation of B-cell activation and proliferation.

1. Cragg MS, Walshe CA, Ivanov AO, Glennie MJ (2005) . The biology of CD20 and its potential as a target for mAb therapy. Curr. Dir. Autoimmun. Current ions in Autoimmunity 8: 140–74. 2. Hardy, Richard (2008) . Chapter 7: B Lymphocyte Development and Biology. In Paul, William.Fundamental Immunology (Book) (6th ed.) . Philadelphia: Lippincott Williams & Wilkins. pp. 237–269. 3. Kuijpers TW, Bende RJ, Baars PA, Grummels A, Derks IA, Dolman KM, Beaumont T, Tedder TF, van Noesel CJ, Eldering E, van Lier RA (January 2010) . CD20 deficiency in humans results in impaired T cell-independent antibody responses. J. Clin. Invest. 120 (1) : 214–22.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

33077 MW

No cross reactivity with other proteins.

6

B-lymphocyte antigen CD20

Cell membrane ; Multi-pass membrane protein . Cell membrane ; Lipid-anchor .

Belongs to the MS4A family.

B-lymphocyte antigen CD20

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.