Anti-CD23/FCER2 Antibody Picoband® fluoro488 Vervoeging

CD23, also known as Fc epsilon RII, or FcεRII, is the low-affinity receptor for IgE, an antibody isotype involved in allergy and resistance to parasites, and is important in regulation of IgE levels. There are two forms of CD23: CD23a and CD23b. CD23a is present on follicular B cells, whereas CD23b requires IL-4 to be expressed on T-cells, monocytes, Langerhans cells, eosinophils, and macrophages. As part of a mapping of multiple probes to specific bands on chromosome 19 by fluorescence in situ hybridization, the FCE2 gene was assigned to 19p13.3. CD23 (FCE2) is a key molecule for B-cell activation and growth. It is the low-affinity receptor for IgE. The truncated molecule can be secreted, then functioning as a potent mitogenic growth factor.

Low affinity immunoglobulin epsilon Fc receptor; Fc-epsilon-RII; Lymphocyte IgE receptor; CD23; Fcer2; Fcer2a

FCER2

14128

P20693

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived mouse CD23 recombinant protein (Position: E50-P331) . Mouse CD23 shares 52% amino acid (aa) sequence identity with human CD23.

Expressed on B-cells.

Flow Cytometry

Adaptive Immunity, B Cells, Hematopoietic Progenitors, Immunoglobulins, Immunology, Lymphoid, Receptors, Stem Cells

Immunogen affinity purified.

Liquid

Low-affinity receptor for immunoglobulin E (IgE) and CR2/CD21. Has essential roles in the regulation of IgE production and in the differentiation of B-cells (it is a B-cell-specific antigen) .

1. Lichtman AH, Abbas AK (2003) . Cellular and molecular immunology. Philadelphia: Saunders. pp. 324–325. 2. Weskamp, G., Ford, J. W., Sturgill, J., Martin, S., Docherty, A. J. P., Swendeman, S., Broadway, N., Hartmann, D., Saftig, P., Umland, S., Sehara-Fujisawa, A., Black, R. A., Ludwig, A., Becherer, J. D., Conrad, D. H., Blobel, C. P.ADAM10 is a principal 'sheddase' of the low-affinity immunoglobulin E receptor CD23.Nature Immun. 7: 1293-1298, 2006.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

37648 MW

No cross reactivity with other proteins.

6

Low affinity immunoglobulin epsilon Fc receptor

Cell membrane ; Single-pass type II membrane protein . Cell membrane ; Lipid-anchor .

Contains 1 C-type lectin domain.

Low affinity immunoglobulin epsilon Fc receptor

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.