Anti-CD30/TNFRSF8 Antibody Picoband® fluoro488 Vervoeging

CD30, also known as TNFRSF8, is a cell membrane protein of the tumor necrosis factor receptor family and tumor marker. This receptor is a positive regulator of apoptosis, and also has been shown to limit the proliferative potential of autoreactive CD8 effector T cells and protect the body against autoimmunity. This gene is mapped to 1p36.22. CD30 is expressed in embryonal carcinoma but not in seminoma and is thus a useful marker in distinguishing between these germ cell tumors. CD30 mast cell activation represents an IgE-independent activation pathway, which is important for understanding cutaneous inflammation associated with mast cells. In addition to those, CD30 is also associated with anaplastic large cell lymphoma.

Tumor necrosis factor receptor superfamily member 8; CD30L receptor; Ki-1 antigen; Lymphocyte activation antigen CD30; CD30; TNFRSF8; CD30, D1S166E

TNFRSF8

943

P28908

Human

No cross-reactivity with other proteins

E.coli-derived human CD30 recombinant protein (Position: T322-K595) . Human CD30 shares 60% and 57% amino acid (aa) sequences identity with mouse and rat CD30, respectively.

Flow Cytometry

Cancer, Cell Type Markers, Cytokines, Immunology, Innate Immunity, Receptors, TNF Superfamily, Tumor Biomarkers, Tumor Immunology

Immunogen affinity purified.

Liquid

Receptor for TNFSF8/CD30L. May play a role in the regulation of cellular growth and transformation of activated lymphoblasts. Regulates gene expression through activation of NF- kappa-B.

1. Fischer, M., Harvima, I. T., Carvalho, R. F. S., Moller, C., Naukkarinen, A., Enblad, G., Nilsson, G. Mast cell CD30 ligand is upregulated in cutaneous inflammation and mediates degranulation-independent chemokine secretion. J. Clin. Invest. 116: 2748-2756, 2006. 2. Gorczyca W, Tsang P, Liu Z, et al. (February 2003) . CD30-positive T-cell lymphomas co-expressing CD15: an immunohistochemical analysis. Int. J. Oncol. 22 (2) : 319–24. 3. Teng LH, Lu DH, Xu QZ, Fu YJ, Yang H, He ZL (2005) . [Expression and diagnostic significance of OCT4, CD117 and CD30 in germ cell tumors]. Zhonghua Bing Li Xue Za Zhi (in Chinese) 34 (11) : 711–5.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

63747 MW

No cross reactivity with other proteins.

6

Tumor necrosis factor receptor superfamily member 8

Isoform 1: Cell membrane; Single-pass type I membrane protein.

Contains 6 TNFR-Cys repeats.

Tumor necrosis factor receptor superfamily member 8

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.