Anti-CD326/Epcam Antibody Picoband® fluoro647 Vervoeging

Epithelial cell adhesion molecule (EpCAM) is a transmembrane glycoprotein mediating Ca2+-independent homotypic cell–cell adhesion in epithelia. This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.

Agouti-related protein; Agrp; Agrt; Art

Epcam

17075

Q99JW5

Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived mouse CD326/Epcam recombinant protein (Position: Q24-A267) .

Expressed in arcuate nucleus and median eminence, adrenal gland (medulla), hypothalamus, testis, and lung.

Flow Cytometry

Calcium Signaling, Cancer, Cardiovascular, Endocrine System, Fatty Acid Oxidation, Fatty Acids, Lipid and Lipoprotein Metabolism, Lipids/Lipoproteins, Metabolic Signaling Pathways, Metabolism, Neurology Process, Neuroscience, Obesity, Pathways and Processes, Redox Metabolism, Signal Transduction, Signaling Pathway

Immunogen affinity purified.

Liquid

Plays a role in weight homeostasis. Involved in the control of feeding behavior through the central melanocortin system. Acts as alpha melanocyte-stimulating hormone antagonist by inhibiting cAMP production mediated by stimulation of melanocortin receptors within the hypothalamus and adrenal gland. Has very low activity with MC5R. Is an inverse agonist for MC3R and MC4R being able to suppress their constitutive activity (By similarity) . It promotes MC3R and MC4R endocytosis in an arrestin-dependent manner (By similarity) .

1. Litvinov, Sergey; et al. (1994) . Ep-CAM: a human epithelial antigen is a homophilic cell–cell adhesion molecule. The Journal of Cell Biology 125 (2) : 437–46. 2. Maetzel, Dorothea; et al. (2009) . Nuclear signalling by tumour-associated antigen EpCAM. Nature Cell Biology 11 (2) : 162–71.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

68762 MW

6

Agouti related neuropeptide

Secreted.

Aryl hydrocarbon receptor nuclear translocator-like protein 1

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.