Anti-CD4 Antilichaam (monoclonaal, CA-4)

CD stands for cluster of differentiation; the number that follows is arbitrarily assigned. In the full designation the cell type and nature and molecular weight of the antigen are given in brackets; for CD4, this is as follows: [T, gp55]. CD4 is present on a subset of T lymphocytes (helper/inducer T cells) and is also expressed at a lower level on monocytes, tissue macrophages and granulocytes. The antigen is involved in binding to MHC class II molecules. The intracellular domain of the antigen is associated with p56lck protein tyrosine kinase.

Flow Cytometry

T-cell surface glycoprotein CD4; T-cell surface antigen T4/Leu-3; W3/25 antigen; CD4; Cd4

CD4

Human (920), Mouse (12504), Rat (24932)

P05540

Human

No cross-reactivity with other proteins

CD4-transfected mouse T-cell hybridoma, 3DT, followed by CD4+ human T-cell CEM cells.

Clone: CA-4

Both mature cathepsin L1 and procathepsin L are found in the upper epidermis. The lower epidermis predominantly contains procathepsin L. In seminiferous tubules expression is greater at stages VI-VII than at stages IX-XII. .

Flow Cytometry, IHC, ICC

Adaptive Immunity, Antiviral Signaling, Hematopoietic Progenitors, Immune System Diseases, Immunology, Lymphoid, Myeloid, Stem Cells, T Cells, T Lymphocytic Lineage

Ascites

Adding 1 ml of PBS buffer will yield a concentration of 100 μg/ml.

Lyophilized

Add 1ml of PBS buffer will yield a concentration of 100ug/ml.

Accessory protein for MHC class-II antigen/T-cell receptor interaction. May regulate T-cell activation.

1. Committee on Human Leukocyte Differentiation Antigens, IUIS WHO Nomenclature Subcommittee : Proposed nomenclature for human leukocyte differentiation antigens. Bull. WHO 5: 809-811, 1984. Note: Alternate: Immunology Today 5: 280 only, 1984. 2. Grakoui, A.; Bromley, S. K.; Sumen, C.; Davis, M. M.; Shaw, A. S.; Allen, P. M.; Dustin, M. L. : The immunological synapse: a molecular machine controlling T cell activation. Science 285: 221-227, 1999.

Store at -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=MA1016

51438 MW

25 kDa

No cross reactivity with other proteins.

6

T-cell surface glycoprotein CD4

Membrane; Single-pass type I membrane protein.

Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

T-cell surface glycoprotein CD4

Mouse IgG1

Mouse ascites fluid, 1.2% sodium acetate, 2mg BSA, with 0.01mg NaN3 as preservative.