Anti-CD46 Konijn Monoklonale Antilichaam

Boster Bio Anti-CD46 Rabbit Monoclonal Antibody catalog # M00377-1. Tested in WB, IHC, ICC/IF applications. This antibody reacts with Human.

Membrane cofactor protein; TLX; Trophoblast leukocyte common antigen; CD46; CD46; MCP, MIC10

CD46

4179

P15529

Human

A synthesized peptide derived from human CD46

Clone: AEI-3

Expressed by all cells except erythrocytes.

WB, IHC, ICC, IF

Cell Type Markers, Complement, Immunology, Innate Immunity

Affinity-chromatography

0.5mg/ml

Liquid

Acts as a cofactor for complement factor I, a serine protease which protects autologous cells against complement- mediated injury by cleaving C3b and C4b deposited on host tissue. May be involved in the fusion of the spermatozoa with the oocyte during fertilization. Also acts as a costimulatory factor for T- cells which induces the differentiation of CD4+ into T-regulatory 1 cells. T-regulatory 1 cells suppress immune responses by secreting interleukin-10, and therefore are thought to prevent autoimmunity. A number of viral and bacterial pathogens seem to exploit this property and ly induce an immunosuppressive phenotype in T-cells by binding to CD46. .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=M00377-1

43747 MW

125 kDa

Membrane cofactor protein

Cytoplasmic vesicle, secretory vesicle, acrosome inner membrane ; Single- pass type I membrane protein . Inner acrosomal membrane of spermatozoa. Internalized upon binding of Measles virus, Herpesvirus 6 or Neisseria gonorrhoeae, which results in an increased susceptibility of infected cells to complement-mediated injury. In cancer cells or cells infected by Neisseria, shedding leads to a soluble peptide.

T-cell surface glycoprotein CD4

Rabbit IgG

Rabbit IgG in phosphate buffered saline, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol, 0.4-0.5mg/ml BSA.