Anti-CD62L/SELL Antilichaam Picoband® 31.0647 Vervoeging

L-selectin, also known as CD62L, is a cell adhesion molecule found on leukocytes. It belongs to the selectin family of proteins, which recognize sialylated carbohydrate groups. It is cleaved by ADAM17. SELL (L-selectin) is a cell surface component that is a member of a family of adhesion/homing receptors which play important roles in leukocyte-endothelial cell interactions. The molecule is composed of multiple domains: one homologous to lectins, one to epidermal growth factor, and two to the consensus repeat units found in C3/C4 binding proteins. L-selectin acts as a homing receptor for leukocytes to enter secondary lymphoid tissues via high endothelial venules. Ligands present on endothelial cells will bind to leukocyte expressing L-selectin, slowing leukocyte trafficking through the blood, and facilitating entry into a secondary lymphoid organ at that point.

L-selectin; CD62 antigen-like family member L; Leukocyte adhesion molecule 1; LAM-1; Leukocyte-endothelial cell adhesion molecule 1; LECAM1; Lymph node homing receptor; Lymphocyte antigen 22; Ly-22; Lymphocyte surface MEL-14 antigen; CD62L; Sell; Lnhr, Ly-22, Ly22

SELL

20343

P18337

Mouse, Rat

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle region of mouse L-selectin, identical to the related rat sequence.

Predominantly expressed in lymphoid tissue. .

Flow Cytometry

Adaptive Immunity, Cardiovascular, Hematopoietic Progenitors, Immunology, Lymphoid, Myeloid, Stem Cells, T Cells, T Lymphocytic Lineage

Immunogen affinity purified.

Liquid

Cell surface adhesion protein. Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (By similarity) . .

1. Entrez Gene: SELL selectin L (lymphocyte adhesion molecule 1) . 2. Cotran; Kumar, Collins (1998) . Robbins Pathologic Basis of Disease. Philadelphia: W.B Saunders Company.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

42288 MW

No cross reactivity with other proteins.

6

L-selectin

Membrane; Single-pass type I membrane protein.

Belongs to the selectin/LECAM family.

L-selectin

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.