Anti-Cd70 Antibody Picoband® fluoro488 Vervoeging

CD70 (Cluster of Differentiation 70) is a protein that in humans is encoded by CD70 gene. The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for TNFRSF27/CD27. It is a surface antigen on activated, but not on resting, T and B lymphocytes. It induces proliferation of costimulated T cells, enhances the generation of cytolytic T cells, and contributes to T cell activation. This cytokine is also reported to play a role in regulating B-cell activation, cytotoxic function of natural killer cells, and immunoglobulin sythesis.

Gasdermin D, gasdermin-D

Cd70

21948

O55237

Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived mouse Cd70 recombinant protein (Position: C36-Q191) .

Brain, placental, and gut tissues.

Flow Cytometry

Atherosclerosis, Cardiovascular, Fatty Acid Oxidation, Fatty Acids, Heart Disease, Lipid and Lipoprotein Metabolism, Lipids/Lipoproteins, Metabolic Signaling Pathways, Metabolism, Neurology Process, Neuroscience, Pathways and Processes, Redox Metabolism, Vascular Inflammation

Immunogen affinity purified.

Liquid

Receptor for MSH (alpha, beta and gamma) and ACTH. This receptor is mediated by G proteins which activate adenylate cyclase. Required for expression of anticipatory patterns of activity and wakefulness during periods of limited nutrient availability and for the normal regulation of circadian clock activity in the brain. .

1. Abolhassani, H., Edwards, E. S. J., Ikinciogullari, A., Jing, H., Borte, S., Buggert, M., Du, L., Matsuda-Lennikov, M., Romano, R., Caridha, R., Bade, S., Zhang, Y., and 21 others. Combined immunodeficiency and Epstein-Barr virus-induced B cell malignancy in humans with inherited CD70 deficiency. J. Exp. Med. 214: 91-106, 2017. 2. Arens, R., Tesselaar, K., Baars, P. A., van Schijndel, G. M. W., Hendriks, J., Pals, S. T., Krimpenfort, P., Borst, J., van Oers, M. H. J., van Lier, R. A. W. Constitutive CD27/CD70 interaction induces expansion of effector-type T cells and results in IFN-gamma-mediated B cell depletion. Immunity 15: 801-812, 2001. 3. Bowman, M. R., Crimmins, M. A. V., Yetz-Aldape, J., Kriz, R., Kelleher, K., Herrmann, S. The cloning of CD70 and its identification as the ligand for CD27. J. Immun. 152: 1756-1761, 1994.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

36043 MW

6

Melanocortin receptor 3

Cell membrane; Multi-pass membrane protein.

Melanocortin receptor 3

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.