Anti-CD80 Antibody Picoband® 31.0550 Vervoeging

Cluster of Differentiation 80 (also CD80 and B7-1) is a protein found on activated B cells and monocytes that provides a costimulatory signal necessary for T cell activation and survival. It is the ligand for two different proteins on the T cell surface: CD28 (for autoregulation and intercellular association) and CTLA-4 (for attenuation of regulation and cellular disassociation) . CD80 works in tandem with CD86 to prime T cells. The CD80 genes encode B7-1 which are structurally similar members of the immunoglobulin superfamily expressed on a variety of hematopoietic cell types. Reeves et al. (1997) stated that B7-1 and B7-2 provide a costimulatory signal to T cells by interacting with CD28 and CTLA4.

T-lymphocyte activation antigen CD80; Activation B7-1 antigen; BB1; CTLA-4 counter-receptor B7.1; B7; CD80; CD80; CD28LG, CD28LG1, LAB7

CD80

941

P33681

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human CD80.

Expressed on activated B-cells, macrophages and dendritic cells.

Flow Cytometry

Adaptive Immunity, B Cells, Hematopoietic Progenitors, Immunology, Lymphoid, Myeloid, Stem Cells

Immunogen affinity purified.

Liquid

Involved in the costimulatory signal essential for T- lymphocyte activation. T-cell proliferation and cytokine production is induced by the binding of CD28, binding to CTLA-4 has opposite effects and inhibits T-cell activation. .

1. Peach, R J; Bajorath J, Naemura J, Leytze G, Greene J, Aruffo A, Linsley P S (Sep. 1995) . Both extracellular immunoglobin-like domains of CD80 contain residues critical for binding T cell surface receptors CTLA-4 and CD28. J. Biol. Chem. (UNITED STATES) 270 (36) : 21181–7. 2. Stamper, C C; Zhang Y, Tobin J F, Erbe D V, Ikemizu S, Davis S J, Stahl M L, Seehra J, Somers W S, Mosyak L (Mar. 2001) . Crystal structure of the B7-1/CTLA-4 complex that inhibits human immune responses. Nature (England) 410 (6828) : 608–11.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

33048 MW

No cross reactivity with other proteins.

6

T-lymphocyte activation antigen CD80

Membrane; Single-pass type I membrane protein.

Contains 1 Ig-like C2-type (immunoglobulin-like) domain.

T-lymphocyte activation antigen CD80

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.