Anti-CD89/FCAR Antilichaam Picoband® 31.0550 Vervoeging

FCAR, Receptor for Fc fragment of IGA, is also known as CD89. Human Fc-alpha receptor (FCAR) is present on a number of cell types, including neutrophils, monocytes, macrophages, and eosinophils. FCAR interacts with aggregated IgAs, such as IgA coated on the surface of an invading microorganism, and mediates several immunologic defense processes such as phagocytosis, antibody-dependent cell-mediated cytotoxicity, and stimulation of the release of inflammatory mediators. FCAR is a glycoprotein of 50 to 100 kD, with diversity on different cell types. FCAR is mapped to 19q13.4. Human COS cells transfected with FCAR cDNA bind to IgA, but not IgG.

Immunoglobulin alpha Fc receptor; IgA Fc receptor; CD89; FCAR; CD89

FCAR

2204

P24071

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence in the middle of human CD89.

Isoform A.1, isoform A.2 and isoform A.3 are differentially expressed between blood and mucosal myeloid cells. Isoform A.1, isoform A.2 and isoform A.3 are expressed in monocytes. Isoform A.1 and isoform A.2 are expressed in alveolar macrophages; however only one isoform is expressed at alveolar macrophages surfaces. .

Flow Cytometry

Cell Type Markers, Immunology

Immunogen affinity purified.

Liquid

Binds to the Fc region of immunoglobulins alpha. Mediates several functions including cytokine production. .

1. Kremer, E. J., Kalatzis, V., Baker, E., Callen, D. F., Sutherland, G. R., Maliszewski, C. R.The gene for the human IgA Fc receptor maps to 19q13.4.Hum. Genet. 89: 107-108, 1992. 2. Maliszewski, C. R., March, C. J., Schoenborn, M. A., Gimpel, S., Shen, L.Expression cloning of a human Fc receptor for IgA.J. Exp. Med. 172: 1665-1672, 1990.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

32265 MW

No cross reactivity with other proteins.

6

Immunoglobulin alpha Fc receptor

Isoform A.1: Cell membrane; Single-pass type I membrane protein.

Immunoglobulin alpha Fc receptor (IgA Fc receptor)

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.