Anti-CD93 Antilichaam fluoro488 Vervoeging

CD93 (Cluster of Differentiation 93) is a protein that in humans is encoded by the CD93 gene. The protein encoded by this gene is a cell-surface glycoprotein and type I membrane protein that was originally identified as a myeloid cell-specific marker. The encoded protein was once thought to be a receptor for C1q, but now is thought to instead be involved in intercellular adhesion and in the clearance of apoptotic cells. The intracellular cytoplasmic tail of this protein has been found to interact with moesin, a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton.

Meiotic recombination protein REC8 homolog; Cohesin Rec8p; REC8; REC8L1

CD93

22918

Q9NPY3

Human

No cross-reactivity with other proteins.

A synthetic peptide corresponding to a sequence at the C-terminus of human CD93, which shares 90.9% amino acid (aa) sequence identity with mouse and rat CD93.

Expressed in testis and thymus. Expressed in the B-cell lines WI-L2-NS and Namalwa.

Flow Cytometry

Vasculature

Immunogen affinity purified.

Liquid

Required during meiosis for separation of sister chromatids and homologous chromosomes. Proteolytic cleavage of REC8 on chromosome arms by separin during anaphase I allows for homologous chromosome separation in meiosis I and cleavage of REC8 on centromeres during anaphase II allows for sister chromatid separation in meiosis II.

1. Danet GH, Luongo JL, Butler G, et al. C1qRp defines a new human stem cell population with hematopoietic and hepatic potential.. Proc Natl Acad Sci USA. 2002; 99 (16) :10441-5. 2. Guan E, Robinson SL, Goodman EB, Tenner AJ. Cell-surface protein identified on phagocytic cells modulates the C1q-mediated enhancement of phagocytosis. J Immunol. 1994; 152 (8) :4005-4016. 3. Guan EN, Burgess WH, Robinson SL, Goodman EB, McTigue KJ, Tenner AJ. Phagocytic cell molecules that bind the collagen-like region of C1q. Involvement in the C1q-mediated enhancement of phagocytosis. J Biol Chem. 1991; 266 (30) :20345-20355.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

56903 MW

6

REC8 meiotic recombination protein

Nucleus. Chromosome. Centromere.

Vesicular acetylcholine transporter

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.