Anti-CD98/Slc3a2 Antibody Picoband® fluoro647 Vervoeging

4F2 cell-surface antigen heavy chain is a protein that in humans is encoded by the SLC3A2 (solute carrier family 3 member 2) gene. Predicted to enable amino acid transmembrane transporter activity and double-stranded RNA binding activity. Predicted to be involved in carboxylic acid transport and viral entry into host cell. Predicted to act upstream of or within response to exogenous dsRNA. Located in apical pole of neuron. Is active in synapse. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and spinal cord. Orthologous to human SLC3A2 (solute carrier family 3 member 2) .

Protein CBFA2T1; Cyclin-D-related protein; Eight twenty one protein; Protein ETO; Protein MTG8; Zinc finger MYND domain-containing protein 2; RUNX1T1; AML1T1; CBFA2T1; CDR; ETO; MTG8; ZMYND2

Slc3a2

17254

P10852

Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived mouse CD98/Slc3a2 recombinant protein (Position: K35-Q497) .

Most abundantly expressed in brain. Lower levels in lung, heart, testis and ovary.

Flow Cytometry

Cancer, Domain Families, Epigenetics and Nuclear Signaling, Oncoproteins/Suppressors, Transcription, Transcription Factors, Tumor Suppressors, Zinc Finger

Immunogen affinity purified.

Liquid

Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes (PubMed:12559562, PubMed:15203199) . Can repress the expression of MMP7 in a ZBTB33-dependent manner (PubMed:23251453) . Can repress transactivation mediated by TCF12 (PubMed:16803958) . Acts as a negative regulator of adipogenesis (By similarity) . The AML1-MTG8/ETO fusion protein frequently found in leukemic cells is involved in leukemogenesis and contributes to hematopoietic stem/progenitor cell self-renewal (PubMed:23812588) .

1. Cantor, J., Slepak, M., Ege, N., Chang, J. T., Ginsberg, M. H. Loss of T cell CD98 H chain specifically ablates T cell clonal expansion and protects from autoimmunity. J. Immun. 187: 851-860, 2011. 2. Courseaux, A., Grosgeorge, J., Gaudray, P., Pannett, A. A. J., Forbes, S. A., Williamson, C., Bassett, D., Thakker, R. V., Teh, B. T., Farnebo, F., Shepherd, J., Skogseid, B., Larsson, C., Giraud, S., Zhang, C. X., Salandre, J., Calender, A. Definition of the minimal MEN1 candidate area based on a 5-Mb integrated map of proximal 11q13. Genomics 37: 354-365, 1996. 3. Feral, C. C., Nishiya, N., Fenczik, C. A., Stuhlmann, H., Slepak, M., Ginsberg, M. H. CD98hc (SLC3A2) mediates integrin signaling. Proc. Nat. Acad. Sci. 102: 355-360, 2005.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

RUNX1 translocation partner 1

Nucleus.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.