Anti-CD99 Antibody Picoband® 0,00647 Vervoeging

CD99 antigen (Cluster of differentiation 99), also known as MIC2 or single-chain type-1 glycoprotein, is a heavily O-glycosylated transmembrane protein that is encoded by the CD99 gene in humans. The protein encoded by this gene is a cell surface glycoprotein involved in leukocyte migration, T-cell adhesion, ganglioside GM1 and transmembrane protein transport, and T-cell death by a caspase-independent pathway. In addition, the encoded protein may have the ability to rearrange the actin cytoskeleton and may also act as an oncosuppressor in osteosarcoma. This gene is found in the pseudoautosomal region of chromosomes X and Y and escapes X-chromosome inactivation. There is a related pseudogene located immediately adjacent to this locus.

Alkaline phosphatase, placental type;3.1.3.1; Alkaline phosphatase Regan isozyme; Placental alkaline phosphatase 1; PLAP-1; ALPP; PLAP

CD99

4267

P14209

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human CD99.

Detected in placenta (at protein level) . .

Flow Cytometry

Cancer, Tags & Cell Markers, Tumor Biomarkers

Immunogen affinity purified.

Liquid

Associates with IFNGR2 to form a receptor for the cytokine interferon gamma (IFNG) (PubMed:7615558, PubMed:2971451, PubMed:7617032, PubMed:10986460) . Ligand binding stimulates activation of the JAK/STAT signaling pathway (PubMed:7673114) . .

1. Banting, G. S., Pym, B., Goodfellow, P. N. Biochemical analysis of an antigen produced by both human sex chromosomes. EMBO J. 4: 1967-1972, 1985. 2. Bernard, A., Aubrit, A., Raynal, B., Phan, D., Boumsell, L. A T cell surface molecule different from CD2 is involved in spontaneous rosette formation with erythrocytes. J. Immun. 140: 1802-1807, 1988. 3. Bixel, M. G., Li, H., Petri, B., Khandoga, A. G., Khandoga, A., Zarbock, A., Wolburg-Buchholz, K., Wolburg, H., Sorokin, L., Zeuschner, D., Maerz, S., Butz, S., Krombach, F., Vestweber, D. CD99 and CD99L2 act at the same site as, but independently of, PECAM-1 during leukocyte diapedesis. Blood 116: 1172-1184, 2010.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

57954 MW

6

Alkaline phosphatase, placental type

Cell membrane; Lipid-anchor, GPI-anchor.

Alkaline phosphatase, placental type

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.