Anti-Cdc42 Antilichaam

Cdc42 proteins are Rho GTPase family members, which act as molecular switches in regulating a variety of biological response pathways including cell motility, cell-cycle progression, gene transcription, and cell transformation. Cdc42 GTPases regulate molecular events by cycling from the inactive GDP-bound state to active GTP-bound forms. The ratio of GDP versus GTP, which is bound to the GTPase, is determined by the opposing effects of guanine nucleotide exchange factors and GTPase activating proteins. Active (GTP-bound) Cdc42 binds to the p21-binding domain of p21-activated protein kinase 1 (PAK1) to regulate downstream signaling cascades.

Our Cdc42 mouse monoclonal primary antibody from PhosphoSolutions is produced in-house. It detects human, mouse, and rat Cdc42 and is antigen affinity purified. It is great for use in ELISA, WB, ICC.

Our Cdc42 mouse monoclonal primary antibody from PhosphoSolutions is produced in-house. It detects human, mouse, and rat Cdc42 and is antigen affinity purified. It is great for use in WB, ICC.

CDC-42, G25K

CDC42

Q8CFN2

Human, Mouse, and Rat

Clone (M430) was generated from a rat recombinant Cdc42 protein. This sequence is highly conserved in human and mouse Cdc42.

Cdc42

M430

Unconjugated

ELISA, WB, ICC

Cell Signaling, Kinase Signaling

Antigen Affinity Purified

PBS + 1 mg/ml BSA, 0.05% NaN3 and 50% glycerol

21

For research use only. Not intended for therapeutic or diagnostic use. Use of all products is subject to our terms and conditions, which can be viewed on our website.

Blue Ice

Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.

Affinity purified rabbit serum

1:500

The antibody detects a 21 kDa* protein in human Jurkat cells, rat A7r5 cells, and mouse brain. The antibody also detects recombinant full length rat Cdc42 fusion protein, but does not recognize a full length human RhoA GST fusion protein.

1:200

Western blots performed on each lot.

Mouse

Liquid

IgM

Rat

Quality Control: WB

AB_3068394