Anti-CDCP1 Antibody Picoband® 0,00647 Vervoeging

CUB domain-containing protein 1 (CDCP1) is a protein that in humans is encoded by the CDCP1 gene. It has also been designated as CD318 (cluster of differentiation 318) and Trask (Transmembrane and associated with src kinases) . CDCP1/Trask is a 140 kD transmembrane glycoprotein with a large extracellular domain (ECD) containing two CUB domains, and a smaller intracellular domain (ICD) containing five tyrosines. The tyrosine phosphorylation of Trask is tightly regulated and reciprocally linked with the state of cell adhesion. The tyrosine phosphorylation of CDCP1 in cultured cells occurs when cells are induced to detach by trypsin or EDTA, or seen spontaneously during mitotic detachment. The overexpression of CDCP1 leads to the loss of cell adhesion and a detached phenotype. CDCP1 is widely expressed in human epithelial tissues, but its phosphorylation is only seen in mitotically detached or shedding cells, consistent with its role in the negative regulation of cell adhesion.

CDCP1

64866

Q9H5V8

Human

E.coli-derived human CDCP1 recombinant protein (Position: E74-V580) . Human CDCP1 shares 85.8% amino acid (aa) sequence identity with mouse CDCP1.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Entrez Gene: CDCP1 CUB domain containing protein 1. 2. Scherl-Mostageer M, Sommergruber W, Abseher R, Hauptmann R, Ambros P, Schweifer N (Jul 2001) . Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer. Oncogene 20 (32) : 4402–8. 3. Spassov DS, Ahuja D, Wong CH, Moasser MM (2011) . The structural features of trask that mediate its anti-adhesive functions. PLoS ONE 6 (4) : e19154.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.