Anti-Cdk2 Antibody Picoband® (monoclonal, 5B12D1) fluoro647 Vervoeging

CDK2, Cyclin-Dependent Kinase2, is also known as P33. The CDK2 protein was highly homologous to p34 (CDC2) kinase and more significantly homologous to Xenopus Eg1 kinase, suggesting that CDK2 is the human homolog of Eg1. The CDK2 gene is mapped to 12q13, the same region to which the CDK4 gene maps. Human cyclin A binds independently to 2 kinases, p34 (cdc2) or p33. In adenovirus-transformed cells, the viral E1A oncoprotein seems to associate with p33/cyclin A but not with p34 (cdc2) /cyclin A. The gene for p33 shares 65% sequence identity with p34 (cdc2) . P33 (cdk2) plays a unique role in cell cycle regulation of vertebrate cells.

Solute carrier family 2, facilitated glucose transporter member 1; Glucose transporter type 1, erythrocyte/brain; GLUT-1; HepG2 glucose transporter; SLC2A1; GLUT1

CDK2

1017

P24941

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human Cdk2 recombinant protein (Position: E81-L298) . Human Cdk2 shares 98.6% amino acid (aa) sequence identity with rat Cdk2.

Clone: 5B12D1

Detected in erythrocytes (at protein level) . Expressed at variable levels in many human tissues.

Flow Cytometry

Channels, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathways, Metabolism, Pathways and Processes, Plasma Membrane, Signal Transduction

Immunogen affinity purified.

Liquid

Facilitative glucose transporter. This isoform may be responsible for constitutive or basal glucose uptake. Has a very broad substrate specificity; can transport a wide range of aldoses including both pentoses and hexoses.

1. Demetrick, D. J., Zhang, H., Beach, D. H.Chromosomal mapping of human CDK2, CDK4, and CDK5 cell cycle kinase genes.Cytogenet. Cell Genet. 66: 72-74, 1994. 2. Tsai, L.-H., Harlow, E., Meyerson, M.Isolation of the human cdk2 gene that encodes the cyclin A- and adenovirus E1A-associated P33 kinase.Nature 353: 174-177, 1991.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

46659 MW

6

Solute carrier family 2 (facilitated glucose transporter), member 1

Cell membrane. Multi-pass membrane protein. Melanosome.

Isocitrate dehydrogenase [NADP] cytoplasmic

Mouse IgG2a

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.