Anti-CEA/CEACAM5 Antibody Picoband® fluoro594 Vervoeging

CEA (Carcinoembryonic antigen) is a glycoprotein involved in cell adhesion. It is normally produced during fetal development, but the production of CEA stops before birth. Therefore, it is not usually present in the blood of healthy adults, although levels are raised in heavy smokers. CEA is a glycosyl phosphatidyl inositol (GPI) -cell surface anchored glycoprotein whose specialized sialofucosylated glycoforms serve as functional colon carcinoma L-selectin and E-selectin ligands, which may be critical to the metastatic dissemination of colon carcinoma cells. CEA and related genes make up the CEA family belonging to the immunoglobulin superfamily. In humans, the carcinoembryonic antigen family consists of 29 genes, 18 of which are normally expressed.

Carcinoembryonic antigen-related cell adhesion molecule 5; Carcinoembryonic antigen; CEA; Meconium antigen 100; CD66e; CEACAM5; CEA

CEACAM5

1048

P06731

Human

No cross-reactivity with other proteins.

E.coli-derived human CEA/CEACAM5 recombinant protein (Position: N553-G678) .

Expressed in columnar epithelial and goblet cells of the colon (at protein level) (PubMed:10436421) . Found in adenocarcinomas of endodermally derived digestive system epithelium and fetal colon.

Flow Cytometry

Adaptive Immunity, Apoptosis, Cell Biology, Immunology, Innate Immunity, NK Cells, T Cells

Immunogen affinity purified.

Liquid

Cell surface glycoprotein that plays a role in cell adhesion, intracellular signaling and tumor progression (PubMed:2803308, PubMed:10910050, PubMed:10864933) . Mediates homophilic and heterophilic cell adhesion with other carcinoembryonic antigen-related cell adhesion molecules, such as CEACAM6 (PubMed:2803308) . Plays a role as an oncogene by promoting tumor progression; induces resistance to anoikis of colorectal carcinoma cells (PubMed:10910050) . (Microbial infection) Receptor for E.coli Dr adhesins. Binding of E.coli Dr adhesins leads to dissociation of the homodimer.

1. Barnett, T.; Goebel, S. J.; Nothdurft, M. A.; Elting, J. J. : Carcinoembryonic antigen family: characterization of cDNAs coding for NCA and CEA and suggestion of nonrandom sequence variation in their conserved loop-domains. Genomics 3: 59-66, 1988. 2. Gold, P.; Freedman, S. O. : Demonstration of tumor-specific antigens in human colonic carcinomata by immunological tolerance and absorption techniques. J. Exp. Med. 121: 439-462, 1965.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

132494 MW

6

Carcinoembryonic antigen related cell adhesion molecule 5

Cytoplasmic granule. Cytoplasmic granules of cytolytic T-lymphocytes and natural killer cells.

Leptin receptor

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.