Anti-Cellulaire oncogene fos (c-Fos) Antilichaam

FUNCTION: Nuclear phosphoprotein which forms a tight but non-covalently linked complex with the JUN/AP-1 transcription factor. In the heterodimer, FOS and JUN/AP-1 basic regions each seems to interact with symmetrical DNA half sites. On TGF-beta activation, forms a multimeric SMAD3/SMAD4/JUN/FOS complex at the AP1/SMAD-binding site to regulate TGF-beta-mediated signaling. Has a critical function in regulating the development of cells destined to form and maintain the skeleton. It is thought to have an important role in signal transduction, cell proliferation and differentiation. In growing cells, activates phospholipid synthesis, possibly by activating CDS1 and PI4K2A. This activity requires Tyr-dephosphorylation and association with the endoplasmic reticulum. SUBUNIT: Heterodimer. Interacts with DSIPI; this interaction inhibits the binding of active AP1 to its target DNA. Interacts with MAFB. SUBCELLULAR LOCATION: Nucleus. INDUCTION: C-fos expression increases upon a variety of stimuli, including growth factors, cytokines, neurotransmitters, polypeptide hormones, stress and cell injury. SIMILARITY: Belongs to the bZIP family. Fos subfamily. SIMILARITY: Contains 1 bZIP domain (Ref: uniprot.org) .

Our Anti-Cellular oncogene fos (c-Fos) mouse monoclonal primary antibody detects bovine, chicken, horse, human, mouse, pig, and rat Cellular oncogene fos (c-Fos), and is affinity-purified. It is validated for use in ICC, IHC-Frozen.

Our Anti-Cellular oncogene fos (c-Fos) mouse monoclonal primary antibody detects bovine, chicken, horse, human, mouse, pig, and rat Cellular oncogene fos (c-Fos), and is affinity-purified. It is validated for use in ICC, IHC-Frozen.

Cellular oncogene fos; G0/G1 switch regulatory protein 7; cFOS

P01100

Bovine, Chicken, Horse, Human, Mouse, Pig, and Rat

Full length, E.coli-derived recombinant human c-FOS protein.

Cellular oncogene fos (c-Fos)

2H2

Unconjugated

ICC, IHC-Frozen

Affinity-purified

Lyophilized from PBS buffer pH 7.2-7.6 with 0.1% trehalose, and sodium azide

See application details

For research use only.

25°C (ambient)

Spin vial briefly before opening. Reconstitute with 100 μL sterile-filtered, ultrapure water to achieve a 1 mg/mL concentration. Centrifuge to remove any insoluble material. Store lyophilized, unopened vial at 2-8°C or lower. After reconstitution, prepare aliquots and store at -20°C for a higher stability. Avoid freeze-thaw cycles.

Protein G purified

1-2 μg/mL

0.5-1 μg/mL

Human. Horse, cow, pig, chicken, rat, mouse.

1-2 μg/mL

Mouse

Lyophilized

IgG1

Human