Anti-CEP135 Antibody Picoband® 0,00647 Vervoeging

Centrosomal protein of 135 kDa is a protein that in humans is encoded by the CEP135 gene. This gene encodes a centrosomal protein, which acts as a scaffolding protein during early centriole biogenesis, and is also required for centriole-centriole cohesion during interphase. Mutations in this gene are associated with autosomal recessive primary microcephaly-8.

CEP135; CEP4; KIAA0635; Centrosomal protein of 135 kDa; Cep135; Centrosomal protein 4

CEP135

9662

Q66GS9

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human CEP135 recombinant protein (Position: E28-E1034) . Human CEP135 shares 82.8% amino acid (aa) sequence identity with mouse CEP135.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Andersen, J. S., Wilkinson, C. J., Mayor, T., Mortensen, P., Nigg, E. A., Mann, M. Proteomic characterization of the human centrosome by protein correlation profiling. Nature 426: 570-574, 2003. 2. Carvalho-Santos, Z., Machado, P., Branco, P., Tavares-Cadete, F., Rodrigues-Martins, A., Pereira-Leal, J. B., Bettencourt-Dias, M. Stepwise evolution of the centriole-assembly pathway. J. Cell Sci. 123: 1414-1426, 2010. 3. Farooq, M., Fatima, A., Mang, Y., Hansen, L., Kjaer, K. W., Baig, S. M., Larsen, L. A., Tommerup, N. A novel splice site mutation in CEP135 is associated with primary microcephaly in a Pakistani family. J. Hum. Genet. 61: 271-273, 2016.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

133 kDa

6

Centrosomal protein 135

Centrosomal protein of 135 kDa

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.