Anti-Ciliaire neurotrofe factor (CNTF) Antilichaam

CNTF is a survival promoting factor for different types of neurons in vitro and in vivo. The essential structural features for the biological function of human CNTF were investigated by Thier, M. et al. They showed that deletion of 14 N-terminal and 18 C-terminal amino acids significantly increased bioactivity compared to wild-type CNTF. FUNCTION: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Nervous system. PHARMACEUTICAL: CNTF is being tested under the name Axokine by Regeneron Pharmaceuticals for treatment of human motor neuron diseases, such as amyotrophic lateral sclerosis (ALS) . As it induces substantial weight loss, preferentially of fat as opposed to lean body mass, it is being used for obesity treatment. SIMILARITY: Belongs to the CNTF family.

Our Anti-Ciliary neurotrophic factor (CNTF) chicken polyclonal primary antibody detects human, mouse, and rat Ciliary neurotrophic factor (CNTF), and is affinity-purified. It is validated for use in ELISA, WB.

Our Anti-Ciliary neurotrophic factor (CNTF) chicken polyclonal primary antibody detects human, mouse, and rat Ciliary neurotrophic factor (CNTF), and is affinity-purified. It is validated for use in ELISA, WB.

Ciliary neurotrophic factor; CNTF

P26441

Human, Mouse, and Rat

Mixture of two peptides from human CNTF (11-25 and 186-200 aa) . Both peptides are highly conserved among human and mouse.

Ciliary neurotrophic factor (CNTF)

Unconjugated

ELISA, WB

Affinity-purified

PBS with 0.02% sodium azide.

For research use only.

2-8°C (on cold packs)

Short term storage at 2-8°C for one week. At -20°C as an undiluted liquid for up to 12 months.

1:50-1:500

1:500-1:2000

CNTF, Cross reactivity to other species is expected.

Chicken

Liquid

IgY

Human