Anti-Ciliaire neurotrofe factor (CNTF) Antilichaam

CNTF is a survival promoting factor for different types of neurons in vitro and in vivo. The essential structural features for the biological function of human CNTF were investigated by Thier, M. et al. They showed that deletion of 14 N-terminal and 18 C-terminal amino acids significantly increased bioactivity compared to wild-type CNTF. FUNCTION: CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy. SUBUNIT: Homodimer. SUBCELLULAR LOCATION: Cytoplasm. TISSUE SPECIFICITY: Nervous system. PHARMACEUTICAL: CNTF is being tested under the name Axokine by Regeneron Pharmaceuticals for treatment of human motor neuron diseases, such as amyotrophic lateral sclerosis (ALS) . As it induces substantial weight loss, preferentially of fat as opposed to lean body mass, it is being used for obesity treatment. SIMILARITY: Belongs to the CNTF family.

Our Anti-Ciliary neurotrophic factor (CNTF) sheep polyclonal primary antibody detects human, mouse, and rat Ciliary neurotrophic factor (CNTF), and is whole serum. It is validated for use in ELISA, IHC-Frozen, WB.

Our Anti-Ciliary neurotrophic factor (CNTF) sheep polyclonal primary antibody detects human, mouse, and rat Ciliary neurotrophic factor (CNTF), and is whole serum. It is validated for use in ELISA, IHC-Frozen, WB.

Ciliary neurotrophic factor

P26441

Human, Mouse, and Rat

Recombinant human CNTF

Ciliary neurotrophic factor (CNTF)

Unconjugated

ELISA, IHC-Frozen, WB

Whole serum

For research use only.

25°C (ambient)

Spin vial briefly before opening. Reconstitute in 100 μL sterile-filtered, ultrapure water. Centrifuge to remove any insoluble material. After reconstitution keep aliquots at -20°C for a higher stability, and at 2-8°C with an appropriate antibacterial agent. Avoid repetitive freeze/thaw cycles. Glycerol (1:1) may be added for an additional stability.

1:500-1:4000

1:500-1:4000

This antibody specifically detects CNTF shown by Western blot. This antiserum to known to react with rat, mouse and human CNTF protein.

Sheep

Lyophilized

Mixed

Human