Anti-CIT Antibody Picoband® HRP Vervoeging

This gene encodes a serine/threonine-protein kinase that functions in cell division. Together with the kinesin KIF14, this protein localizes to the central spindle and midbody, and functions to promote efficient cytokinesis. This protein is involved in central nervous system development. Polymorphisms in this gene are associated with bipolar disorder and risk for schizophrenia. Alternative splicing results in multiple transcript variants.

CIT; CRIK; KIAA0949; STK21; Citron Rho-interacting kinase; CRIK; EC 2.7.11.1; Serine/threonine-protein kinase 21

CIT

11113

O14578

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human CIT recombinant protein (Position: Q470-H1505) . Human CIT shares 95.2% and 94.7% amino acid (aa) sequence identity with mouse and rat CIT, respectively.

WB, IHC, ELISA

Immunogen affinity purified.

Liquid

1. Basit, S., Al-Harbi, K. M., Alhijji, S. A. M., Albalawi, A. M., Alharby, E., Eldardear, A., Samman, M. I. CIT, a gene involved in neurogenic cytokinesis, is mutated in human primary microcephaly. Hum. Genet. 135: 1199-1207, 2016. 2. Di Cunto, F., Calautti, E., Hsiao, J., Ong, L., Topley, G., Turco, E., Dotto, G. P. Citron Rho-interacting kinase, a novel tissue-specific ser/thr kinase encompassing the Rho-Rac-binding protein citron. J. Biol. Chem. 273: 29706-29711, 1998. 3. Di Cunto, F., Imarisio, S., Hirsch, E., Broccoli, V., Bulfone, A., Migheli, A., Atzori, C., Turco, E., Triolo, R., Dotto, G. P., Silengo, L., Altruda, F. Defective neurogenesis in citron kinase knockout mice by altered cytokinesis and massive apoptosis. Neuron 28: 115-127, 2000.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing.

231 kDa

Citron rho-interacting serine/threonine kinase

Citron Rho-interacting kinase

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4.