Anti-CLASP2 Antibody Picoband® fluoro550 Vervoeging

CLASP2 (CLIP-associating protein 2) is a brain specific protein belongs to CLASP family. CLASP1 and CLASP2 regulate microtubule plus-end dynamics in brine cortex. CLASP2 is required for the orientation of stabilized microtubules toward the leading edge, It may act at the cell cortex to enhance the frequency of rescue of depolymerizing microtubules by attaching their plus-ends to cortical platforms. Phosphorylation of CLASP2 by GSK3B may negatively regulate binding to microtubule lattices in lamella.

Segment polarity protein dishevelled homolog DVL-3; Dishevelled-3; DSH homolog 3; DVL3; KIAA0208

CLASP2

23122

O75122

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human CLASP2 recombinant protein (Position: A266-D1230) .

Flow Cytometry

Cardiogenesis, Cardiovascular, Cytoplasmic, Neurogenesis, Neurology Process, Neuroscience, Signaling Pathways, Stem Cells

Immunogen affinity purified.

Liquid

May play a role in the signal transduction pathway mediated by multiple Wnt genes.

1. Akhmanova, A., Hoogenraad, C. C., Drabek, K., Stepanova, T., Dortland, B., Verkerk, T., Vermeulen, W., Burgering, B. M., De Zeeuw, C. I., Grosveld, F., Galjart, N. CLASPs are CLIP-115 and -170 associating proteins involved in the regional regulation of microtubule dynamics in motile fibroblasts. Cell 104: 923-935, 2001. 2. Hartz, P. A. Personal Communication. Baltimore, Md. 11/1/2013. 3. Ishikawa, K., Nagase, T., Suyama, M., Miyajima, N., Tanaka, A., Kotani, H., Nomura, N., Ohara, O. Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. DNA Res. 5: 169-176, 1998.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

78055 MW

6

Segment polarity protein dishevelled homolog DVL-3

Cytoplasm .

Segment polarity protein dishevelled homolog DVL-3

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.