Anti-CLDN11 Antibody Picoband® 0,00647 Vervoeging

Claudin-11 is a protein that in humans is encoded by the CLDN11 gene. This gene encodes a member of the claudin family. Claudins are integral membrane proteins and components of tight junction strands. Tight junction strands serve as a physical barrier to prevent solutes and water from passing freely through the paracellular space between epithelial or endothelial cell sheets, and also play critical roles in maintaining cell polarity and signal transductions. The protein encoded by this gene is a major component of central nervous system (CNS) myelin and plays an important role in regulating proliferation and migration of oligodendrocytes. Mouse studies showed that the gene deficiency results in deafness and loss of the Sertoli cell epithelial phenotype in the testis. This protein is a tight junction protein at the human blood-testis barrier (BTB), and the BTB disruption is related to a dysfunction of this gene. Alternatively spliced transcript variants encoding different isoforms have been identified.

CLDN11; OSP; OTM; Claudin-11; Oligodendrocyte-specific protein

CLDN11

5010

O75508

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the C-terminus of human CLDN11, which shares 85% amino acid (aa) sequence identity with both mouse and rat CLDN11.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Bronstein, J. M., Kozak, C. A., Chen, X.-N., Wu, S., Danciger, M., Korenberg, J. R., Farber, D. B. Chromosomal localization of murine and human oligodendrocyte-specific protein genes. Genomics 34: 255-257, 1996. 2. Gow, A., Southwood, C. M., Li, J. S., Pariali, M., Riordan, G. P., Brodie, S. E., Danias, J., Bronstein, J. M., Kachar, B., Lazzarini, R. A. CNS myelin and Sertoli cell tight junction strands are absent in Osp/claudin-11 null mice. Cell 99: 649-659, 1999. 3. Maheras, K. J., Peppi, M., Ghoddoussi, F., Galloway, M. P., Perrine, S. A., Gow, A. Absence of Claudin 11 in CNS myelin perturbs behavior and neurotransmitter levels in mice. Sci. Rep. 8: 3798, 2018.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

22 kDa

6

Claudin 11

Claudin-11

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.