Anti-CLEC6A Antilichaam

Boster Bio Anti-CLEC6A Antibody catalog # A11863. Tested in WB applications. This antibody reacts with Human, Mouse, Rat.

C-type lectin domain family 6 member A ; C-type lectin superfamily member 10; Dendritic cell-associated C-type lectin 2; DC-associated C-type lectin 2; Dectin-2

CLEC6A

Q6EIG7

Human, Mouse, Rat

A synthetic peptide corresponding to residues in Human CLEC6A

Expressed in lung, spleen, lymph node, leukocytes, bone marrow, tonsils and dendritic cells. Strongly expressed in purified monocytes and weakly in B-cells. In peripheral blood cells, preferentially expressed in plasmacytoids rather than myeloids.

WB

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen and the purity is > 95% (by SDS-PAGE) .

1 mg/mL

Liquid

Binds high-mannose carbohydrates in a Ca (2+) -dependent manner (PubMed:28652405) . Functional receptor for alpha-mannans on C.albicans hypheas. Plays an important role in the host defense against C.albicans infection by inducing TH17 cell differentiation. Recognizes also, in a mannose-dependent manner, allergens from house dust mite and fungi, by promoting cysteinyl leukotriene production. Recognizes soluble elements from the eggs of Shistosoma mansoni altering adaptive immune responses. Transduces signals through an Fc receptor gamma chain /FCER1G and Syk-CARD9-NF-kappa-B-dependent pathway (By similarity) .

Store at -20°C for one year. For short term storage and frequent use, store at 4°C for up to one month. Avoid repeated freeze-thaw cycles.

https://www.bosterbio.com/msds?sku=A11863

23998 MW

WB: 1:500-1:1000

C-type lectin domain family 6 member A

Membrane ; Single-pass type II membrane protein .

C-type lectin domain family 6 member A

Rabbit IgG, 1mg/mL in PBS with 0.02% sodium azide, 50% glycerol, pH7.2