Anti-CLIP170 Antilichaam

CLIP170 was initially identified as a new type of intermediate filament associated protein that is highly expressed in Reed-Sternberg cells, the tumoral cells diagnostic for Hodgkin's disease. Later experiments showed that it is located at microtubule plus ends and is required for the binding of endocytic carrier vesicles. CLIP170 has also been suggested to act with LIS1, a protein implicated in brain development, to regulate dynein/dynactin binding microtubules. Other studies suggest that CLIP170 can influence the formation of lamellipodia and cell invasion by invasive breast cancer cells by regulating the release of kinesin and IQGAP1 from a complex of those proteins, CLIP170 and Rac1. At least two isoforms of CLIP170 are known to exist.

Boster Bio Anti-CLIP170 Antibody (Catalog # A08907) . Tested in ELISA, WB, IF applications. This antibody reacts with Human, Mouse, Rat.

RSN, CLIP, CYLN1, CLIP170, CLIP-170, RSN, CAP-Gly domain-containing linker protein 1, Cytoplasmic linker protein 1

CLIP1

P30622

Human, Mouse, Rat

CLIP170 antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human CLIP170. The immunogen is located within amino acids 1340 - 1390 of CLIP170.

Detected in dendritic cells (at protein level) . Highly expressed in the Reed-Sternberg cells of Hodgkin disease.

ELISA, WB, IF

Homeostasis

CLIP170 Antibody is affinity chromatography purified via peptide column.

1 mg/mL

Liquid

Binds to the plus end of microtubules and regulates the dynamics of the microtubule cytoskeleton. Promotes microtubule growth and microtubule bundling. Links cytoplasmic vesicles to microtubules and thereby plays an important role in intracellular vesicle trafficking. Plays a role macropinocytosis and endosome trafficking.

CLIP170 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. Avoid repeated freeze-thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

https://www.bosterbio.com/msds?sku=A08907

162246 MW

CAP-GLY domain containing linker protein 1

Cytoplasm . Cytoplasm, cytoskeleton

CAP-GLY domain containing linker protein 1

IgG

CLIP170 Antibody is supplied in PBS containing 0.02% sodium azide.