Anti-CNPase/CNP Antibody Picoband® fluoro488 Vervoeging

2',3'-Cyclic-nucleotide 3'-phosphodiesterase, also known as CNPase, is an enzyme that in humans is encoded by the CNP gene. And this gene is mapped to 17q21.2. CNPase is named for its ability to catalyze the phosphodiester hydrolysis of 2',3'-cyclic nucleotides to 2'-nucleotides. CNPase is thought to play a critical role in the events leading up to myelination. Additionally, CNPase has been demonstrated to inhibit the replication of HIV-1 and other primate lentiviruses by binding the retroviral Gag protein and inhibiting the genesis of nascent viral particles.

2',3'-cyclic-nucleotide 3'-phosphodiesterase; CNP; CNPase;3.1.4.37; CNP

CNP

1267

P09543

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human CNPase/CNP recombinant protein (Position: M1-I421) .

Flow Cytometry

Cell Type Marker, Cell Type Markers, Neurodegenerative Disease, Neurology Process, Neuroscience, Tags & Cell Markers

Immunogen affinity purified.

Liquid

May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin. .

1. Entrez Gene: CNP 2',3'-cyclic nucleotide 3' phosphodiesterase. 2. Hinman JD, Chen CD, Oh SY, Hollander W, Abraham CR (Jan 2008) . Age-dependent accumulation of ubiquitinated 2',3'-cyclic nucleotide 3'-phosphodiesterase in myelin lipid rafts. Glia. 56 (1) : 118–33. 3. Sprinkle TJ, Lanclos KD, Lapp DF (Jul 1992) . Assignment of the human 2',3'-cyclic nucleotide 3'-phosphohydrolase gene to chromosome 17.Genomics. 13 (3) : 877–80.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

47579 MW

6

2',3'-cyclic-nucleotide 3'-phosphodiesterase

Membrane; Lipid-anchor. Melanosome. Firmly bound to membrane structures of brain white matter. Identified by mass spectrometry in melanosome fractions from stage I to stage IV.

2',3'-cyclic-nucleotide 3'-phosphodiesterase

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.