Anti-collageen type II/COL2A1 Antibody Picoband® 0,00647 Vervoeging

Collagen, type II, alpha 1 (primary osteoarthritis, spondyloepiphyseal dysplasia, congenital), also known as COL2A1, is a human gene that provides instructions for the production of the pro-alpha1 (II) chain of type II collagen. This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene.

COL2A1

1280

P02458

Human, Mouse, Rat

E.coli-derived human Collagen Type II/COL2A1 recombinant protein (Position: G1217-A1241) . Human COL2A1 shares 92% and 96% amino acid (aa) sequence identity with mouse and rat COL2A1, respectively.

Flow Cytometry

Immunogen affinity purified.

Liquid

1. Ahmad, N. N., Ala-Kokko, L., Knowlton, R. G., Jimenez, S. A., Weaver, E. J., Maguire, J. I., Tasman, W., Prockop, D. J. Stop codon in the procollagen II gene (COL2A1) in a family with the Stickler syndrome (arthro-ophthalmopathy) . Proc. Nat. Acad. Sci. 88: 6624-6627, 1991. 2. Ahmad, N. N., Ala-Kokko, L., Knowlton, R. G., Weaver, E. J., Maguire, J. I., Tasman, W., Prockop, D. J. A stop codon in the gene for type II procollagen (COL2A1) causes one variant of arthro-ophthalmopathy (the Stickler syndrome) . (Abstract) Am. J. Hum. Genet. 47 (suppl.) : A206 only, 1990. 3. Ahmad, N. N., Dimascio, J., Knowlton, R. G., Tasman, W. S. Stickler syndrome: a mutation in the nonhelical 3-prime end of type II procollagen gene. Arch. Ophthal. 113: 1454-1457, 1995.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

142 kDa

6

IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.