Anti-Cortisol Bindende Globulin/SERPINA6 Antibody Picoband® 310647 Vervoeging

Corticosteroid-binding globulin (CBG), also known as Serpin A6 is a protein that in humans is encoded by the SERPINA6 gene. It is mapped 14q32.13. This gene encodes an alpha-globulin protein with corticosteroid-binding properties. This is the major transport protein for glucorticoids and progestins in the blood of most vertebrates. The gene localizes to a chromosomal region containing several closely related serine protease inhibitors which may have evolved by duplication events.

Corticosteroid-binding globulin; CBG; Serpin A6; Transcortin; SERPINA6; CBG

SERPINA6

866

P08185

Human

No cross-reactivity with other proteins

A synthetic peptide corresponding to a sequence at the N-terminus of human Cortisol Binding Globulin.

Plasma; synthesized in liver. Has also been identified in a number of glycocorticoid responsive cells.

Flow Cytometry

Cancer, Lipid Metabolism, Metabolism, Signal Transduction

Immunogen affinity purified.

Liquid

Major transport protein for glucocorticoids and progestins in the blood of almost all vertebrate species. .

1. Buss, C., Schuelter, U., Hesse, J., Moser, D., Phillips, D. I., Hellhammer, D., Meyer, J. Haploinsufficiency of the SEPRINA6 gene is associated with severe muscle fatigue: a de novo mutation in corticosteroid-binding globulin deficiency. J. Neural Transm. 114: 563-569, 2007. 2. Torpy, D. J., Bachmann, A. W., Grice, J. E., Fitzgerald, S. P., Phillips, P. J., Whitworth, J. A., Jackson, R. V. Familial corticosteroid-binding globulin deficiency due to a novel null mutation: association with fatigue and relative hypotension. J. Clin. Endocr. Metab. 86: 3692-3700, 2001.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

45141 MW

No cross reactivity with other proteins.

6

Corticosteroid-binding globulin

Secreted.

Belongs to the serpin family.

Corticosteroid-binding globulin

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.