Anti-CPEB4 Antibody Picoband® 31.0647 Vervoeging

Cytoplasmic polyadenylation element binding protein 4 (CPEB4) is a sequence-specific RNA-binding protein that participates in translational control. CPEB4 is a member of the CPEB family, which includes CPEB1, CPEB2, CPEB3, and CPEB4, all of which share structure and sequence identity in the C-terminal RNA-binding domain (RBD) . CPEB4 has two domains: one that is structured for RNA binding and one that is unstructured and low complexity that has no known function.

Dual specificity protein phosphatase 3; Dual specificity protein phosphatase VHR; Vaccinia H1-related phosphatase; VHR; DUSP3; VHR

CPEB4

80315

Q17RY0

Human, Mouse, Rat

No cross-reactivity with other proteins.

E.coli-derived human CPEB4 recombinant protein (Position: D3-N462) .

Testis specific.

Flow Cytometry

Signal Transduction

Immunogen affinity purified.

Liquid

Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2.

1. Nagase, T., Kikuno, R., Hattori, A., Kondo, Y., Okumura, K., Ohara, O. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. DNA Res. 7: 347-355, 2000. 2. Ortiz-Zapater, E., Pineda, D., Martinez-Bosch, N., Fernandez-Miranda, G., Iglesias, M., Alameda, F., Moreno, M., Eliscovich, C., Eyras, E., Real, F. X., Mendez, R., Navarro, P. Key contribution of CPEB4-mediated translational control to cancer progression. Nature Med. 18: 83-90, 2011. 3. Parras, A., Anta, H., Santos-Galindo, M., Swarup, V., Elorza, A., Nieto-Gonzalez, J. L., Pico, S., Hernandez, I. H., Diaz-Hernandez, J. I., Belloc, E., Rodolosse, A., Parikshak, N. N., Penagarikano, O., Fernandez-Chacon, R., Irimia, M., Navarro, P., Geschwind, D. H., Mendez, R., Lucas, J. J. Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing. Nature 560: 441-446, 2018.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

17828 MW

6

Dual specificity phosphatase 3

Nucleus.

Delta-1-pyrroline-5-carboxylate synthase

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.