Anti-CRABP1 Antibody Picoband® fluoro488 Vervoeging

Cellular retinoic acid-binding protein 1 is a protein that in humans is encoded by the CRABP1 gene. This gene encodes a specific binding protein for a vitamin A family member and is thought to play an important role in retinoic acid-mediated differentiation and proliferation processes. It is structurally similar to the cellular retinol-binding proteins, but binds only retinoic acid at specific sites within the nucleus, which may contribute to vitamin A-ed differentiation in epithelial tissue.

DAZ-associated protein 1; Deleted in azoospermia-associated protein 1; DAZAP1

CRABP1

1381

P29762

Human

No cross-reactivity with other proteins.

E.coli-derived human CRABP1 recombinant protein (Position: R60-E118) .

Mainly expressed in testis. Expressed to a lower level in thymus. Weakly or not expressed in heart, liver, brain, placenta, lung, skeletal muscle, kidney and pancreas.

Flow Cytometry

Cancer, Cell Biology, Energy Metabolism, Energy Transfer Pathways, Metabolic Signaling Pathways, Metabolism, Oxidative Stress, Pathways and Processes, Redox Metabolism, Signal Transduction

Immunogen affinity purified.

Liquid

RNA-binding protein, which may be required during spermatogenesis.

1. Flagiello, D., Apiou, F., Gibaud, A., Poupon, M. F., Dutirllaux, B., Malfoy, B. Assignment of the genes for cellular retinoic acid binding protein 1 (CRABP1) and 2 (CRABP2) to human chromosome band 15q24 and 1q21.3, respectively, by in situ hybridization. Cytogenet. Cell Genet. 76: 17-18, 1997. 2. Geurts van Kessel, A., de Leeuw, H., Dekker, E. J., Rijks, L., Spurr, N., Ledbetter, D., Kootwijk, E., Vaessen, M. J. Localization of the cellular retinoic acid binding protein (CRABP) gene relative to the acute promyelocytic leukemia-associated breakpoint on human chromosome 15. Hum. Genet. 87: 201-204, 1991. 3. Guidez, F., Parks, S., Wong, H., Jovanovic, J. V., Mays, A., Gilkes, A. F., Mills, K. I., Guillemin, M.-C., Hobbs, R. M., Pandolfi, P. P., de The, H., Solomon, E., Grimwade, D. RAR-alpha-PLZF overcomes PLZF-mediated repression of CRABPI, contributing to retinoid resistance in t (11;17) acute promyelocytic leukemia. Proc. Nat. Acad. Sci. 104: 18694-18699, 2007.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

49229 MW

6

DAZ associated protein 1

Nucleus. Cytoplasm.

Chromaffin granule amine transporter

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.