Anti-CRABP2 Antibody Picoband® fluoro488 Vervoeging

Cellular retinoic acid-binding protein 2 is a cytoplasmic binding protein that in humans is encoded by the CRABP2 gene. This gene encodes a member of the retinoic acid (RA, a form of vitamin A) binding protein family and lipocalin/cytosolic fatty-acid binding protein family. The protein is a cytosol-to-nuclear shuttling protein, which facilitates RA binding to its cognate receptor complex and transfer to the nucleus. It is involved in the retinoid signaling pathway, and is associated with increased circulating low-density lipoprotein cholesterol. Alternatively spliced transcript variants encoding the same protein have been found for this gene.

Myelin-oligodendrocyte glycoprotein; MOG

CRABP2

1382

P29373

Human

No cross-reactivity with other proteins.

E.coli-derived human CRABP2 recombinant protein (Position: R60-D117) .

Found exclusively in the CNS, where it is localized on the surface of myelin and oligodendrocyte cytoplasmic membranes.

Flow Cytometry

Cancer, Lipid Metabolism, Metabolism, Signal Transduction

Immunogen affinity purified.

Liquid

Mediates homophilic cell-cell adhesion (By similarity) . Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Acts as a receptor for rubella virus.

1. Elder, J. T., Astrom, A., Pettersson, U., Voorhees, J. J., Trent, J. M. Assignment of the human CRABP-II gene to chromosome 1q21 by nonisotopic in situ hybridization. Hum. Genet. 89: 487-490, 1992. 2. Flagiello, D., Apiou, F., Gibaud, A., Poupon, M. F., Dutrillaux, B., Malfoy, B. Assignment of the genes for cellular retinoic acid binding protein 1 (CRABP1) and 2 (CRABP2) to human chromosome band 15q24 and 1q21.3, respectively, by in situ hybridization. Cytogenet. Cell Genet. 76: 17-18, 1997. 3. Giguere, V., Lyn, S., Yip, P., Siu, C.-H., Amin, S. Molecular cloning of cDNA encoding a second cellular retinoic acid-binding protein. Proc. Nat. Acad. Sci. 87: 6233-6237, 1990.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Myelin oligodendrocyte glycoprotein

Cell membrane. Multi-pass membrane protein. Single-pass type I membrane protein.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.