Anti-CRBN Antibody Picoband®

Cereblon is a protein that in humans is encoded by the CRBN gene. This gene encodes a protein related to the Lon protease protein family. In rodents and other mammals this gene product is found in the cytoplasm localized with a calcium channel membrane protein, and is thought to play a role in brain development. Mutations in this gene are associated with autosomal recessive nonsyndromic cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene.

Boster Bio Anti-CRBN Antibody Picoband® catalog # A00983-1. Tested in WB, ICC/IF, Flow Cytometry, ELISA applications. This antibody reacts with Human, Mouse, Rat. The brand Picoband indicates this is a premium antibody that guarantees superior quality, high affinity, and strong signals with minimal background in Western blot applications. Only our best-performing antibodies are designated as Picoband, ensuring unmatched performance.

CRBN; AD-006; Protein cereblon

CRBN

51185

Q96SW2

Human, Mouse, Rat

No cross-reactivity with other proteins

E.coli-derived human CRBN recombinant protein (Position: M1-H378) . Human CRBN shares 95% amino acid (aa) sequence identity with both mouse and rat CRBN.

WB, ICC/IF, Flow Cytometry, ELISA

Immunogen affinity purified.

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

Lyophilized

Adding 0.2 ml of distilled water will yield a concentration of 500 μg/ml.

1. Fischer, E. S., Bohm, K., Lydeard, J. R., Yang, H., Stadler, M. B., Cavadini, S., Nagel, J., Serluca, F., Acker, V., Lingaraju, G. M., Tichkule, R. B., Schebesta, M., and 9 others. Structure of the DDB1-CRBN E3 ubiquitin ligase in complex with thalidomide. Nature 512: 49-53, 2014. 2. Higgins, J. J., Hao, J., Kosofsky, B. E., Rajadhyaksha, A. M. Dysregulation of large-conductance Ca (2+) -activated K (+) channel expression in nonsyndromal mental retardation due to a cereblon p.R419X mutation. Neurogenetics 9: 219-223, 2008. 3. Higgins, J. J., Pucilowska, J., Lombardi, R. Q., Rooney, J. P. A mutation in a novel ATP-dependent Lon protease gene in a kindred with mild mental retardation. Neurology 63: 1927-1931, 2004.

At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.

https://www.bosterbio.com/msds?sku=A00983-1

51 kDa

51 kDa

6

Cereblon

Protein cereblon

Rabbit IgG

Each vial contains 4 mg Trehalose, 0.9 mg NaCl, 0.2 mg Na2HPO4.