Anti-CRTC3 Antibody Picoband® 0,00647 Vervoeging

CREB-regulated transcription coactivator 3 is a protein that in humans is encoded by the CRTC3 gene. This gene is a member of the CREB regulated transcription coactivator gene family. This family regulates CREB-dependent gene transcription in a phosphorylation-independent manner and may be selective for cAMP-responsive genes. The protein encoded by this gene may induce mitochondrial biogenesis and attenuate catecholamine signaling in adipose tissue. A translocation event between this gene and Notch coactivator mastermind-like gene 2, which results in a fusion protein, has been reported in mucoepidermoid carcinomas. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Lymphotactin; C motif chemokine 1; Cytokine SCM-1; Lymphotaxin; Small-inducible cytokine C1; Xcl1; Lptn; Ltn; Scyc1

CRTC3

64784

Q6UUV7

Human, Monkey

No cross-reactivity with other proteins.

E.coli-derived human CRTC3 recombinant protein (Position: R116-L619) .

Expressed in activated CD8 (+) T cells. In the thymus, expressed by medullary thymic epithelial cells.

Flow Cytometry

Chemokines, Immunology, Innate Immunity

Immunogen affinity purified.

Liquid

Chemotactic activity for lymphocytes but not for monocytes or neutrophils. In thymus, mediates medullary accumulation of thymic dendritic cells and contributes to regulatoy T cell development, playing a role in self-tolerance establishment.

1. Iourgenko, V., Zhang, W., Mickanin, C., Daly, I., Jiang, C., Hexham, J. M., Orth, A. P., Miraglia, L., Meltzer, J., Garza, D., Chirn, G.-W., McWhinnie, E., and 9 others. Identification of a family of cAMP response element-binding protein coactivators by genome-scale functional analysis in mammalian cells. Proc. Nat. Acad. Sci. 100: 12147-12152, 2003. 2. Song, Y., Altarejos, J., Goodarzi, M. O., Inoue, H., Guo, X., Berdeaux, R., Kim, J.-H., Goode, J., Igata, M., Paz, J. C., Hogan, M. F., Singh, P. K., and 12 others. CRTC3 links catecholamine signalling to energy balance. Nature 468: 933-939, 2010. 3. Wu, Z., Huang, X., Feng, Y., Handschin, C., Feng, Y., Gullicksen, P. S., Bare, O., Labow, M., Spiegelman, B., Stevenson, S. C. Transducer of regulated CREB-binding proteins (TORCs) induce PGC-1-alpha transcription and mitochondrial biogenesis in muscle cells. Proc. Nat. Acad. Sci. 103: 14379-14384, 2006.

At -20 ̊C for one year from date of receipt. Avoid repeated freezing and thawing. Protect from light.

6

Chemokine (C motif) ligand 1

Secreted.

Rabbit IgG

Each vial contains 50% glycerol, 0.9% NaCl, 0.2% Na2HPO4, 0.02% NaN3.