Anti-CTDSP2 Antilichaam

CTDSPs are C-class phosphatases that act on Ser 5 of the Pol II C-terminal domain (CTD) to decrease transcription [PMID:15681389]. CTDSP enzymatic activity is required for REST function, and knockdown of CTDSP induces the neuronal differentiation of mouse embryonic carcinoma P19 cells. CTDSP2 has been shown to enhance TGF-β signaling by the dephosphorylation of SMAD proteins and attenuates androgen receptor-mediated transcription [PMID:16724108]. It negatively regulates RNA polymerase II transcription by controlling the transition from initiation/capping to processive transcript elongation. It was recruited by REST to neuronal genes that contain RE-1 elements, leading to neuronal gene silencing in non-neuronal cells[PMID: 12721286].

Boster Bio Anti-CTDSP2 Antibody catalog # A10355-2. Tested in WB, IHC, ELISA applications. This antibody reacts with Human, Mouse, Rat.

CTDSP2

O14595

Human, Mouse, Rat

E.coli-derived human CTDSP2 recombinant protein (Position: H3-L268) .

WB, IHC, ELISA

Immunogen affinity purified.

500 μg/mL

Liquid

12 months from date of receipt, -20°C as supplied. 6 months 2 to 8°C after reconstitution. Avoid repeated freezing and thawing.

https://www.bosterbio.com/datasheet?sku=A10355-2

500 μg/mL antibody with PBS,0.02% NaN3, 1 mg BSA and 50% glycerol.